Possibilities and challenges for quantitative optical sensing of hydrogen peroxide

Moßhammer, M; Kühl, M; Koren, K

Possibilities and challenges for quantitative optical sensing of hydrogen peroxide

Moßhammer, M

Kühl, M

Koren, K

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Publication Type:: Journal Article
Citation:: Chemosensors, 2017, 5 (4)
Issue Date:: 2017-12-01

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Field	Value	Language
dc.contributor.author	Moßhammer, M https://orcid.org/0000-0002-7296-8673	en_US
dc.contributor.author	Kühl, M https://orcid.org/0000-0002-1792-4790	en_US
dc.contributor.author	Koren, K https://orcid.org/0000-0002-7537-3114	en_US
dc.date.issued	2017-12-01	en_US
dc.identifier.citation	Chemosensors, 2017, 5 (4)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/125015
dc.description.abstract	© 2017 by the authors. Hydrogen peroxide (H2O2) plays a key role in many biological processes spanning from coral bleaching, over cell signaling to aging. However, exact quantitative assessments of concentrations and dynamics of H2O2 remain challenging due to methodological limitations- especially at very low (sub μM) concentrations. Most published optical detection schemes for H2O2 suffer from irreversibility, cross sensitivity to other analytes such as other reactive oxygen species (ROS) or pH, instability, temperature dependency or limitation to a specific medium. We review optical detection schemes for H2O2, compare their specific advantages and disadvantages, and discuss current challenges and new approaches for quantitative optical H2O2 detection, with a special focus on luminescence-based measurements. We also review published concentration ranges for H2O2 in natural habitats, and physiological concentrations in different biological samples to provide guidelines for future experiments and sensor development in biomedical and environmental science.	en_US
dc.relation.ispartof	Chemosensors	en_US
dc.relation.isbasedon	10.3390/chemosensors5040028	en_US
dc.title	Possibilities and challenges for quantitative optical sensing of hydrogen peroxide	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	5	en_US
utslib.for	0301 Analytical Chemistry	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - C3 - Climate Change Cluster
utslib.copyright.status	open_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	5	en_US

Abstract:

© 2017 by the authors. Hydrogen peroxide (H2O2) plays a key role in many biological processes spanning from coral bleaching, over cell signaling to aging. However, exact quantitative assessments of concentrations and dynamics of H2O2 remain challenging due to methodological limitations- especially at very low (sub μM) concentrations. Most published optical detection schemes for H2O2 suffer from irreversibility, cross sensitivity to other analytes such as other reactive oxygen species (ROS) or pH, instability, temperature dependency or limitation to a specific medium. We review optical detection schemes for H2O2, compare their specific advantages and disadvantages, and discuss current challenges and new approaches for quantitative optical H2O2 detection, with a special focus on luminescence-based measurements. We also review published concentration ranges for H2O2 in natural habitats, and physiological concentrations in different biological samples to provide guidelines for future experiments and sensor development in biomedical and environmental science.

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http://hdl.handle.net/10453/125015