Phylodynamics of foot-and-mouth disease virus O/PanAsia in Vietnam 2010-2014

Brito, B; Pauszek, SJ; Eschbaumer, M; Stenfeldt, C; De Carvalho Ferreira, HC; Vu, LT; Phuong, NT; Hoang, BH; Tho, ND; Dong, PV; Minh, PQ; Long, NT; King, DP; Knowles, NJ; Dung, DH; Rodriguez, LL; Arzt, J

Phylodynamics of foot-and-mouth disease virus O/PanAsia in Vietnam 2010-2014

Pauszek, SJ Eschbaumer, M Stenfeldt, C De Carvalho Ferreira, HC Vu, LT Phuong, NT Hoang, BH Tho, ND Dong, PV Minh, PQ Long, NT King, DP

Knowles, NJ Dung, DH Rodriguez, LL Arzt, J

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Publication Type:: Journal Article
Citation:: Veterinary Research, 2017, 48 (1)
Issue Date:: 2017-04-13

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Field	Value	Language
dc.contributor.author	Brito, B https://orcid.org/0000-0001-6122-2596	en_US
dc.contributor.author	Pauszek, SJ	en_US
dc.contributor.author	Eschbaumer, M	en_US
dc.contributor.author	Stenfeldt, C	en_US
dc.contributor.author	De Carvalho Ferreira, HC	en_US
dc.contributor.author	Vu, LT	en_US
dc.contributor.author	Phuong, NT	en_US
dc.contributor.author	Hoang, BH	en_US
dc.contributor.author	Tho, ND	en_US
dc.contributor.author	Dong, PV	en_US
dc.contributor.author	Minh, PQ	en_US
dc.contributor.author	Long, NT	en_US
dc.contributor.author	King, DP https://orcid.org/0000-0002-6959-2708	en_US
dc.contributor.author	Knowles, NJ	en_US
dc.contributor.author	Dung, DH	en_US
dc.contributor.author	Rodriguez, LL	en_US
dc.contributor.author	Arzt, J https://orcid.org/0000-0002-7517-7893	en_US
dc.date.available	2017-03-15	en_US
dc.date.issued	2017-04-13	en_US
dc.identifier.citation	Veterinary Research, 2017, 48 (1)	en_US
dc.identifier.issn	0928-4249	en_US
dc.identifier.uri	http://hdl.handle.net/10453/125239
dc.description.abstract	© 2017 The Author(s). Foot-and-mouth disease virus (FMDV) is endemic in Vietnam, a country that plays an important role in livestock trade within Southeast Asia. The large populations of FMDV-susceptible species in Vietnam are important components of food production and of the national livelihood. In this study, we investigated the phylogeny of FMDV O/PanAsia in Vietnam, reconstructing the virus' ancestral host species (pig, cattle or buffalo), clinical stage (subclinical carrier or clinically affected) and geographical location. Phylogenetic divergence time estimation and character state reconstruction analyses suggest that movement of viruses between species differ. While inferred transmissions from cattle to buffalo and pigs and from pigs to cattle are well supported, transmission from buffalo to other species, and from pigs to buffalo may be less frequent. Geographical movements of FMDV O/PanAsia virus appears to occur in all directions within the country, with the South Central Coast and the Northeast regions playing a more important role in FMDV O/PanAsia spread. Genetic selection of variants with changes at specific sites within FMDV VP1 coding region was different depending on host groups analyzed. The overall ratio of non-synonymous to synonymous nucleotide changes was greater in pigs compared to cattle and buffalo, whereas a higher number of individual amino acid sites under positive selection were detected in persistently infected, subclinical animals compared to viruses collected from clinically diseased animals. These results provide novel insights to understand FMDV evolution and its association with viral spread within endemic countries. These findings may support animal health organizations in their endeavor to design animal disease control strategies in response to outbreaks.	en_US
dc.relation.ispartof	Veterinary Research	en_US
dc.relation.isbasedon	10.1186/s13567-017-0424-7	en_US
dc.subject.classification	Veterinary Sciences	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Buffaloes	en_US
dc.subject.mesh	Cattle	en_US
dc.subject.mesh	Foot-and-Mouth Disease Virus	en_US
dc.subject.mesh	Foot-and-Mouth Disease	en_US
dc.subject.mesh	Cattle Diseases	en_US
dc.subject.mesh	Bayes Theorem	en_US
dc.subject.mesh	Phylogeny	en_US
dc.subject.mesh	Vietnam	en_US
dc.subject.mesh	Phylogeography	en_US
dc.title	Phylodynamics of foot-and-mouth disease virus O/PanAsia in Vietnam 2010-2014	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	48	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	0707 Veterinary Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	open_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	48	en_US

Abstract:

© 2017 The Author(s). Foot-and-mouth disease virus (FMDV) is endemic in Vietnam, a country that plays an important role in livestock trade within Southeast Asia. The large populations of FMDV-susceptible species in Vietnam are important components of food production and of the national livelihood. In this study, we investigated the phylogeny of FMDV O/PanAsia in Vietnam, reconstructing the virus' ancestral host species (pig, cattle or buffalo), clinical stage (subclinical carrier or clinically affected) and geographical location. Phylogenetic divergence time estimation and character state reconstruction analyses suggest that movement of viruses between species differ. While inferred transmissions from cattle to buffalo and pigs and from pigs to cattle are well supported, transmission from buffalo to other species, and from pigs to buffalo may be less frequent. Geographical movements of FMDV O/PanAsia virus appears to occur in all directions within the country, with the South Central Coast and the Northeast regions playing a more important role in FMDV O/PanAsia spread. Genetic selection of variants with changes at specific sites within FMDV VP1 coding region was different depending on host groups analyzed. The overall ratio of non-synonymous to synonymous nucleotide changes was greater in pigs compared to cattle and buffalo, whereas a higher number of individual amino acid sites under positive selection were detected in persistently infected, subclinical animals compared to viruses collected from clinically diseased animals. These results provide novel insights to understand FMDV evolution and its association with viral spread within endemic countries. These findings may support animal health organizations in their endeavor to design animal disease control strategies in response to outbreaks.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/125239