Chiral determination and assay of optical isomers in clandestine drug laboratory samples using LC-MSMS

Popovic, A; McBriar, T; He, P; Beavis, A

Chiral determination and assay of optical isomers in clandestine drug laboratory samples using LC-MSMS

Popovic, A

McBriar, T He, P Beavis, A

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Publication Type:: Journal Article
Citation:: Analytical Methods, 2017, 9 (22), pp. 3380 - 3387
Issue Date:: 2017-06-14

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Field	Value	Language
dc.contributor.author	Popovic, A https://orcid.org/0000-0001-5075-4714	en_US
dc.contributor.author	McBriar, T	en_US
dc.contributor.author	He, P	en_US
dc.contributor.author	Beavis, A https://orcid.org/0000-0001-6259-7699	en_US
dc.date.issued	2017-06-14	en_US
dc.identifier.citation	Analytical Methods, 2017, 9 (22), pp. 3380 - 3387	en_US
dc.identifier.issn	1759-9660	en_US
dc.identifier.uri	http://hdl.handle.net/10453/125890
dc.description.abstract	© The Royal Society of Chemistry 2017. Many illicit drugs produced in clandestine laboratories exist as optical isomers, and due to their differing pharmacological properties, it is necessary to determine their respective amounts in a sample. Furthermore, the chemical signature of a clandestine laboratory sample could yield information about possible synthetic routes and product origin. The aim of this study was to optimise a method for the chiral resolution of amphetamine-type stimulants (ATS) and subsequently validate a liquid chromatography-tandem mass spectrometry (LC-MSMS) method for their simultaneous identification and quantification. This study used a CHIROBIOTIC V2 column, which contains interactive chiral additives, to successfully resolve the ATS enantiomers. The correlation coefficients (r2) acquired through the optimised method were determined to range from 0.9956 to 0.9989. Recovery was evaluated at two different concentrations and found to be between 78% and 102%. The method was proved to be fit for purpose as the repeatability and intermediate precision values were found to be below 2.40% and 5.18%, respectively. Five clandestine laboratory samples were analysed using the validated method and found to predominantly contain dextromethylamphetamine in concentrations ranging from 39.7 ppm to 5880 ppm. Dextroamphetamine was also identified in much smaller concentrations.	en_US
dc.relation.ispartof	Analytical Methods	en_US
dc.relation.isbasedon	10.1039/c6ay03125k	en_US
dc.title	Chiral determination and assay of optical isomers in clandestine drug laboratory samples using LC-MSMS	en_US
dc.type	Journal Article
utslib.citation.volume	22	en_US
utslib.citation.volume	9	en_US
utslib.for	0301 Analytical Chemistry	en_US
utslib.for	0399 Other Chemical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
utslib.copyright.status	closed_access
pubs.issue	22	en_US
pubs.publication-status	Published	en_US
pubs.volume	9	en_US

Abstract:

© The Royal Society of Chemistry 2017. Many illicit drugs produced in clandestine laboratories exist as optical isomers, and due to their differing pharmacological properties, it is necessary to determine their respective amounts in a sample. Furthermore, the chemical signature of a clandestine laboratory sample could yield information about possible synthetic routes and product origin. The aim of this study was to optimise a method for the chiral resolution of amphetamine-type stimulants (ATS) and subsequently validate a liquid chromatography-tandem mass spectrometry (LC-MSMS) method for their simultaneous identification and quantification. This study used a CHIROBIOTIC V2 column, which contains interactive chiral additives, to successfully resolve the ATS enantiomers. The correlation coefficients (r2) acquired through the optimised method were determined to range from 0.9956 to 0.9989. Recovery was evaluated at two different concentrations and found to be between 78% and 102%. The method was proved to be fit for purpose as the repeatability and intermediate precision values were found to be below 2.40% and 5.18%, respectively. Five clandestine laboratory samples were analysed using the validated method and found to predominantly contain dextromethylamphetamine in concentrations ranging from 39.7 ppm to 5880 ppm. Dextroamphetamine was also identified in much smaller concentrations.

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http://hdl.handle.net/10453/125890