Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases

Chen, H; McGowan, EM; Ren, N; Lal, S; Nassif, N; Shad-Kaneez, F; Qu, X; Lin, Y

Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases

Chen, H McGowan, EM

Ren, N Lal, S

Nassif, N

Shad-Kaneez, F Qu, X Lin, Y

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Publication Type:: Journal Article
Citation:: Biomarker Insights, 2018, 13
Issue Date:: 2018-07-03

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Field	Value	Language
dc.contributor.author	Chen, H	en_US
dc.contributor.author	McGowan, EM https://orcid.org/0000-0001-6371-3751	en_US
dc.contributor.author	Ren, N	en_US
dc.contributor.author	Lal, S https://orcid.org/0000-0002-0911-0850	en_US
dc.contributor.author	Nassif, N https://orcid.org/0000-0003-2675-8322	en_US
dc.contributor.author	Shad-Kaneez, F	en_US
dc.contributor.author	Qu, X	en_US
dc.contributor.author	Lin, Y https://orcid.org/0000-0002-4637-9701	en_US
dc.date.available	2018-05-02	en_US
dc.date.issued	2018-07-03	en_US
dc.identifier.citation	Biomarker Insights, 2018, 13	en_US
dc.identifier.uri	http://hdl.handle.net/10453/125955
dc.description.abstract	© The Author(s) 2018. Cardiovascular disease (CVD) is the leading cause of death in the world and our approach to the control and management of CVD mortality is limited. Nattokinase (NK), the most active ingredient of natto, possesses a variety of favourable cardiovascular effects and the consumption of Natto has been linked to a reduction in CVD mortality. Recent research has demonstrated that NK has potent fibrinolytic activity, antihypertensive, anti-atherosclerotic, and lipid-lowering, antiplatelet, and neuroprotective effects. This review covers the major pharmacologic effects of NK with a focus on its clinical relevance to CVD. It outlines the advantages of NK and the outstanding issues pertaining to NK pharmacokinetics. Available evidence suggests that NK is a unique natural compound that possesses several key cardiovascular beneficial effects for patients with CVD and is therefore an ideal drug candidate for the prevention and treatment of CVD. Nattokinase is a promising alternative in the management of CVD.	en_US
dc.relation.ispartof	Biomarker Insights	en_US
dc.relation.isbasedon	10.1177/1177271918785130	en_US
dc.title	Nattokinase: A Promising Alternative in Prevention and Treatment of Cardiovascular Diseases	en_US
dc.type	Journal Article
utslib.citation.volume	13	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
utslib.for	1101 Medical Biochemistry and Metabolomics	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access
pubs.publication-status	Published	en_US
pubs.volume	13	en_US

Abstract:

© The Author(s) 2018. Cardiovascular disease (CVD) is the leading cause of death in the world and our approach to the control and management of CVD mortality is limited. Nattokinase (NK), the most active ingredient of natto, possesses a variety of favourable cardiovascular effects and the consumption of Natto has been linked to a reduction in CVD mortality. Recent research has demonstrated that NK has potent fibrinolytic activity, antihypertensive, anti-atherosclerotic, and lipid-lowering, antiplatelet, and neuroprotective effects. This review covers the major pharmacologic effects of NK with a focus on its clinical relevance to CVD. It outlines the advantages of NK and the outstanding issues pertaining to NK pharmacokinetics. Available evidence suggests that NK is a unique natural compound that possesses several key cardiovascular beneficial effects for patients with CVD and is therefore an ideal drug candidate for the prevention and treatment of CVD. Nattokinase is a promising alternative in the management of CVD.

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http://hdl.handle.net/10453/125955