Thalamic control of dorsomedial striatum regulates internal state to guide goal-directed action selection

Bradfield, LA; Balleine, BW

Thalamic control of dorsomedial striatum regulates internal state to guide goal-directed action selection

Bradfield, LA

Balleine, BW

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Publication Type:: Journal Article
Citation:: Journal of Neuroscience, 2017, 37 (13), pp. 3721 - 3733
Issue Date:: 2017-03-29

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Field	Value	Language
dc.contributor.author	Bradfield, LA https://orcid.org/0000-0003-3921-0745	en_US
dc.contributor.author	Balleine, BW	en_US
dc.date.available	2017-02-13	en_US
dc.date.issued	2017-03-29	en_US
dc.identifier.citation	Journal of Neuroscience, 2017, 37 (13), pp. 3721 - 3733	en_US
dc.identifier.issn	0270-6474	en_US
dc.identifier.uri	http://hdl.handle.net/10453/126100
dc.description.abstract	© 2017 the authors. We (Bradfield et al., 2013) have demonstrated previously that parafascicular thalamic nucleus (PF)-controlled neurons in the posterior dorsomedial striatum (pDMS) are critical for interlacing new and existing action–outcome contingencies to control goal-directed action. Based on these findings, it was suggested that animals with a dysfunctional PF–pDMS pathway might suffer a deficit in creating or retrieving internal contexts or “states” on which such information could become conditional. To assess this hypothesis more directly, rats were given a disconnection treatment using contralateral cytotoxic lesions of the PF and pDMS (Group CONTRA) or ipsilateral control lesions (Group IPSI) and trained to press a right and left lever for sucrose and pellet outcomes, after which these contingencies were reversed. The rats were then given an outcome devaluation test (all experiments) and a test of outcome-specific reinstatement (Experi-ments 1 and 3). We found that devaluation performance was intact for both groups after training of initial contingencies, but impaired for Group CONTRA after reversal. However, performance was restored by additional reversal training. Furthermore, when tested a second time after reversal training, rats in both groups demonstrated responding in accordance with the original contingencies, providing direct evidence of modulation of action selection by state. Finally, we found that external context could substitute for internal state and so could rescue responding in Group CONTRA, but only in the reinstatement test. Together, these findings suggest that animals use internal state information to guide action selection and that this information is modulated by the PF–pDMS pathway.	en_US
dc.relation.ispartof	Journal of Neuroscience	en_US
dc.relation.isbasedon	10.1523/JNEUROSCI.3860-16.2017	en_US
dc.subject.classification	Neurology & Neurosurgery	en_US
dc.subject.mesh	Thalamus	en_US
dc.subject.mesh	Corpus Striatum	en_US
dc.subject.mesh	Nerve Net	en_US
dc.subject.mesh	Neural Pathways	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Rats	en_US
dc.subject.mesh	Rats, Wistar	en_US
dc.subject.mesh	Behavior, Animal	en_US
dc.subject.mesh	Goals	en_US
dc.subject.mesh	Learning	en_US
dc.subject.mesh	Cues	en_US
dc.subject.mesh	Choice Behavior	en_US
dc.subject.mesh	Task Performance and Analysis	en_US
dc.subject.mesh	Male	en_US
dc.title	Thalamic control of dorsomedial striatum regulates internal state to guide goal-directed action selection	en_US
dc.type	Journal Article
utslib.citation.volume	13	en_US
utslib.citation.volume	37	en_US
utslib.for	1101 Medical Biochemistry and Metabolomics	en_US
utslib.for	1702 Cognitive Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
utslib.for	17 Psychology and Cognitive Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.issue	13	en_US
pubs.publication-status	Published	en_US
pubs.volume	37	en_US

Abstract:

© 2017 the authors. We (Bradfield et al., 2013) have demonstrated previously that parafascicular thalamic nucleus (PF)-controlled neurons in the posterior dorsomedial striatum (pDMS) are critical for interlacing new and existing action–outcome contingencies to control goal-directed action. Based on these findings, it was suggested that animals with a dysfunctional PF–pDMS pathway might suffer a deficit in creating or retrieving internal contexts or “states” on which such information could become conditional. To assess this hypothesis more directly, rats were given a disconnection treatment using contralateral cytotoxic lesions of the PF and pDMS (Group CONTRA) or ipsilateral control lesions (Group IPSI) and trained to press a right and left lever for sucrose and pellet outcomes, after which these contingencies were reversed. The rats were then given an outcome devaluation test (all experiments) and a test of outcome-specific reinstatement (Experi-ments 1 and 3). We found that devaluation performance was intact for both groups after training of initial contingencies, but impaired for Group CONTRA after reversal. However, performance was restored by additional reversal training. Furthermore, when tested a second time after reversal training, rats in both groups demonstrated responding in accordance with the original contingencies, providing direct evidence of modulation of action selection by state. Finally, we found that external context could substitute for internal state and so could rescue responding in Group CONTRA, but only in the reinstatement test. Together, these findings suggest that animals use internal state information to guide action selection and that this information is modulated by the PF–pDMS pathway.

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http://hdl.handle.net/10453/126100