Animal models of COPD: What do they tell us?

Jones, B; Donovan, C; Liu, G; Gomez, HM; Chimankar, V; Harrison, CL; Wiegman, CH; Adcock, IM; Knight, DA; Hirota, JA; Hansbro, PM

Animal models of COPD: What do they tell us?

Jones, B Donovan, C Liu, G

Gomez, HM Chimankar, V Harrison, CL Wiegman, CH Adcock, IM Knight, DA Hirota, JA Hansbro, PM

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Publication Type:: Journal Article
Citation:: Respirology, 2017, 22 (1), pp. 21 - 32
Issue Date:: 2017-01-01

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Field	Value	Language
dc.contributor.author	Jones, B	en_US
dc.contributor.author	Donovan, C	en_US
dc.contributor.author	Liu, G https://orcid.org/0000-0002-0489-2638	en_US
dc.contributor.author	Gomez, HM	en_US
dc.contributor.author	Chimankar, V	en_US
dc.contributor.author	Harrison, CL	en_US
dc.contributor.author	Wiegman, CH	en_US
dc.contributor.author	Adcock, IM	en_US
dc.contributor.author	Knight, DA	en_US
dc.contributor.author	Hirota, JA	en_US
dc.contributor.author	Hansbro, PM https://orcid.org/0000-0002-4741-3035	en_US
dc.date.available	2016-08-02	en_US
dc.date.issued	2017-01-01	en_US
dc.identifier.citation	Respirology, 2017, 22 (1), pp. 21 - 32	en_US
dc.identifier.issn	1323-7799	en_US
dc.identifier.uri	http://hdl.handle.net/10453/126195
dc.description.abstract	© 2016 Asian Pacific Society of Respirology COPD is a major cause of global mortality and morbidity but current treatments are poorly effective. This is because the underlying mechanisms that drive the development and progression of COPD are incompletely understood. Animal models of disease provide a valuable, ethically and economically viable experimental platform to examine these mechanisms and identify biomarkers that may be therapeutic targets that would facilitate the development of improved standard of care. Here, we review the different established animal models of COPD and the various aspects of disease pathophysiology that have been successfully recapitulated in these models including chronic lung inflammation, airway remodelling, emphysema and impaired lung function. Furthermore, some of the mechanistic features, and thus biomarkers and therapeutic targets of COPD identified in animal models are outlined. Some of the existing therapies that suppress some disease symptoms that were identified in animal models and are progressing towards therapeutic development have been outlined. Further studies of representative animal models of human COPD have the strong potential to identify new and effective therapeutic approaches for COPD.	en_US
dc.relation.ispartof	Respirology	en_US
dc.relation.isbasedon	10.1111/resp.12908	en_US
dc.subject.classification	Respiratory System	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Pulmonary Disease, Chronic Obstructive	en_US
dc.subject.mesh	Disease Models, Animal	en_US
dc.subject.mesh	Disease Progression	en_US
dc.subject.mesh	Airway Remodeling	en_US
dc.title	Animal models of COPD: What do they tell us?	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	22	en_US
utslib.for	1101 Medical Biochemistry and Metabolomics	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	22	en_US

Abstract:

© 2016 Asian Pacific Society of Respirology COPD is a major cause of global mortality and morbidity but current treatments are poorly effective. This is because the underlying mechanisms that drive the development and progression of COPD are incompletely understood. Animal models of disease provide a valuable, ethically and economically viable experimental platform to examine these mechanisms and identify biomarkers that may be therapeutic targets that would facilitate the development of improved standard of care. Here, we review the different established animal models of COPD and the various aspects of disease pathophysiology that have been successfully recapitulated in these models including chronic lung inflammation, airway remodelling, emphysema and impaired lung function. Furthermore, some of the mechanistic features, and thus biomarkers and therapeutic targets of COPD identified in animal models are outlined. Some of the existing therapies that suppress some disease symptoms that were identified in animal models and are progressing towards therapeutic development have been outlined. Further studies of representative animal models of human COPD have the strong potential to identify new and effective therapeutic approaches for COPD.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/126195