An epizootic of Chlamydia psittaci equine reproductive loss associated with suspected spillover from native Australian parrots article

Jenkins, C; Jelocnik, M; Micallef, ML; Galea, F; Taylor-Brown, A; Bogema, DR; Liu, M; O'Rourke, B; Chicken, C; Carrick, J; Polkinghorne, A

An epizootic of Chlamydia psittaci equine reproductive loss associated with suspected spillover from native Australian parrots article

Jenkins, C

Jelocnik, M

Micallef, ML Galea, F Taylor-Brown, A Bogema, DR

Liu, M

O'Rourke, B Chicken, C Carrick, J Polkinghorne, A

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Publication Type:: Journal Article
Citation:: Emerging Microbes and Infections, 2018, 7 (1)
Issue Date:: 2018-12-01

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Field	Value	Language
dc.contributor.author	Jenkins, C https://orcid.org/0000-0002-5966-072X	en_US
dc.contributor.author	Jelocnik, M https://orcid.org/0000-0003-1340-2562	en_US
dc.contributor.author	Micallef, ML	en_US
dc.contributor.author	Galea, F	en_US
dc.contributor.author	Taylor-Brown, A	en_US
dc.contributor.author	Bogema, DR https://orcid.org/0000-0001-7013-7326	en_US
dc.contributor.author	Liu, M https://orcid.org/0000-0001-8312-0734	en_US
dc.contributor.author	O'Rourke, B	en_US
dc.contributor.author	Chicken, C	en_US
dc.contributor.author	Carrick, J	en_US
dc.contributor.author	Polkinghorne, A	en_US
dc.date.available	2018-04-09	en_US
dc.date.issued	2018-12-01	en_US
dc.identifier.citation	Emerging Microbes and Infections, 2018, 7 (1)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/126536
dc.description.abstract	© 2018 The Author(s). Chlamydia psittaci is an avian pathogen capable of spill-over infections to humans. A parrot C. psittaci strain was recently detected in an equine reproductive loss case associated with a subsequent cluster of human C. psittaci infections. In this study, we screened for C. psittaci in cases of equine reproductive loss reported in regional New South Wales, Australia during the 2016 foaling season. C. psittaci specific-PCR screening of foetal and placental tissue samples from cases of equine abortion (n = 161) and foals with compromised health status (n = 38) revealed C. psittaci positivity of 21.1% and 23.7%, respectively. There was a statistically significant geographical clustering of cases ~170 km inland from the mid-coast of NSW (P < 0.001). Genomic analysis and molecular typing of C. psittaci positive samples from this study and the previous Australian equine index case revealed that the equine strains from different studs in regional NSW were clonal, while the phylogenetic analysis revealed that the C. psittaci strains from both Australian equine disease clusters belong to the parrot-associated 6BC clade, again indicative of spill-over of C. psittaci infections from native Australian parrots. The results of this work suggest that C. psittaci may be a more significant agent of equine reproductive loss than thought. A range of studies are now required to evaluate (a) the exact role that C. psittaci plays in equine reproductive loss; (b) the range of potential avian reservoirs and factors influencing infection spill-over; and (c) the risk that these equine infections pose to human health.	en_US
dc.relation.ispartof	Emerging Microbes and Infections	en_US
dc.relation.isbasedon	10.1038/s41426-018-0089-y	en_US
dc.subject.mesh	Aborted Fetus	en_US
dc.subject.mesh	Placenta	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Parrots	en_US
dc.subject.mesh	Horses	en_US
dc.subject.mesh	Chlamydophila psittaci	en_US
dc.subject.mesh	Pregnancy Complications, Infectious	en_US
dc.subject.mesh	Horse Diseases	en_US
dc.subject.mesh	DNA, Bacterial	en_US
dc.subject.mesh	Pregnancy	en_US
dc.subject.mesh	Genome, Bacterial	en_US
dc.subject.mesh	Australia	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Psittacosis	en_US
dc.subject.mesh	Molecular Typing	en_US
dc.title	An epizootic of Chlamydia psittaci equine reproductive loss associated with suspected spillover from native Australian parrots article	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	7	en_US
utslib.for	0605 Microbiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	open_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	7	en_US

Abstract:

© 2018 The Author(s). Chlamydia psittaci is an avian pathogen capable of spill-over infections to humans. A parrot C. psittaci strain was recently detected in an equine reproductive loss case associated with a subsequent cluster of human C. psittaci infections. In this study, we screened for C. psittaci in cases of equine reproductive loss reported in regional New South Wales, Australia during the 2016 foaling season. C. psittaci specific-PCR screening of foetal and placental tissue samples from cases of equine abortion (n = 161) and foals with compromised health status (n = 38) revealed C. psittaci positivity of 21.1% and 23.7%, respectively. There was a statistically significant geographical clustering of cases ~170 km inland from the mid-coast of NSW (P < 0.001). Genomic analysis and molecular typing of C. psittaci positive samples from this study and the previous Australian equine index case revealed that the equine strains from different studs in regional NSW were clonal, while the phylogenetic analysis revealed that the C. psittaci strains from both Australian equine disease clusters belong to the parrot-associated 6BC clade, again indicative of spill-over of C. psittaci infections from native Australian parrots. The results of this work suggest that C. psittaci may be a more significant agent of equine reproductive loss than thought. A range of studies are now required to evaluate (a) the exact role that C. psittaci plays in equine reproductive loss; (b) the range of potential avian reservoirs and factors influencing infection spill-over; and (c) the risk that these equine infections pose to human health.

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http://hdl.handle.net/10453/126536