The postmortem distribution of bromadiolone and its metabolite-benzylideneacetone in poisoned dogs

Zhao, D; Yang, Z; Wei, Z; Fu, S; Liu, L; Yun, K

The postmortem distribution of bromadiolone and its metabolite-benzylideneacetone in poisoned dogs

Zhao, D Yang, Z Wei, Z Fu, S

Liu, L Yun, K

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Publisher:: Forensic Medicine Association of China
Publication Type:: Journal Article
Citation:: Zhongguo Fayixue Zazhi, 2017, 32 (3), pp. 294 - 297
Issue Date:: 2017-06

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Field	Value	Language
dc.contributor.author	Zhao, D	en_US
dc.contributor.author	Yang, Z	en_US
dc.contributor.author	Wei, Z	en_US
dc.contributor.author	Fu, S https://orcid.org/0000-0002-6238-3612	en_US
dc.contributor.author	Liu, L	en_US
dc.contributor.author	Yun, K	en_US
dc.date.issued	2017-06	en_US
dc.identifier.citation	Zhongguo Fayixue Zazhi, 2017, 32 (3), pp. 294 - 297	en_US
dc.identifier.issn	1001-5728	en_US
dc.identifier.uri	http://hdl.handle.net/10453/126676
dc.description.abstract	Objective To study the postmortem distribution of Bromadiolone and its metabolite-Benzylideneacetone in dogs and provide an experimental evidence for the sampling of Bromadiolone poisoning cases. Methods The dogs were given 2LD50 and 4LD50 Bromadiolone by intragastric administration. Anatomy was conducted immediately after death and samples of body fluids and viscera (heart blood; peripheral blood, bile, urine, heart, liver, spleen, lung, kidney, brain, urinary bladder, left leg muscle, stomach, stomach contents, pancreas) were collected and detected after the dogs poisoning death. The Bromadiolon and its metabolite-Benzylideneacetone contents in samples were analyzed by GC/MS. Results Hemorrhagic symptoms came out at 3d after Bromadiolone delivery and deaths occurred at (178.40±20.94)h after intoxication. The postmortem distribution of Bromadiolon and its metabolite-Benzylideneacetone in dogs was as following: 2LD50 Bromadiolon: bile>urine, liver, heart, kidney>heart blood, peripheral blood, spleen, lung and so on. Benzylideneacetone: the content in bile, urine, heart blood, peripheral blood, lung, stomach contents are higher. 4LD50 Bromadiolon: bile, urine>liver, peripheral blood>heart blood, stomach contents and others. Benzylideneacetone: contents in bile, urine and lung are higher. Conclusion The postmortem distribution of Bromadiolon and its metabolite- Benzylideneacetone in dogs is uneven, contents in bile, urine, liver, heart blood and peripheral blood are higher, which are suggested for forensic toxicological analysis in Bromadiolon poisonig case.	en_US
dc.publisher	Forensic Medicine Association of China	en_US
dc.relation.ispartof	Zhongguo Fayixue Zazhi	en_US
dc.relation.isbasedon	10.13618/j.issn.1001-5728.2017.03.016	en_US
dc.title	The postmortem distribution of bromadiolone and its metabolite-benzylideneacetone in poisoned dogs	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	32	en_US
utslib.for	0399 Other Chemical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CCET - Centre for Clean Energy Technology
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
utslib.copyright.status	closed_access
pubs.consider-herdc	true	en_US
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	32	en_US

Abstract:

Objective To study the postmortem distribution of Bromadiolone and its metabolite-Benzylideneacetone in dogs and provide an experimental evidence for the sampling of Bromadiolone poisoning cases. Methods The dogs were given 2LD50 and 4LD50 Bromadiolone by intragastric administration. Anatomy was conducted immediately after death and samples of body fluids and viscera (heart blood; peripheral blood, bile, urine, heart, liver, spleen, lung, kidney, brain, urinary bladder, left leg muscle, stomach, stomach contents, pancreas) were collected and detected after the dogs poisoning death. The Bromadiolon and its metabolite-Benzylideneacetone contents in samples were analyzed by GC/MS. Results Hemorrhagic symptoms came out at 3d after Bromadiolone delivery and deaths occurred at (178.40±20.94)h after intoxication. The postmortem distribution of Bromadiolon and its metabolite-Benzylideneacetone in dogs was as following: 2LD50 Bromadiolon: bile>urine, liver, heart, kidney>heart blood, peripheral blood, spleen, lung and so on. Benzylideneacetone: the content in bile, urine, heart blood, peripheral blood, lung, stomach contents are higher. 4LD50 Bromadiolon: bile, urine>liver, peripheral blood>heart blood, stomach contents and others. Benzylideneacetone: contents in bile, urine and lung are higher. Conclusion The postmortem distribution of Bromadiolon and its metabolite- Benzylideneacetone in dogs is uneven, contents in bile, urine, liver, heart blood and peripheral blood are higher, which are suggested for forensic toxicological analysis in Bromadiolon poisonig case.

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http://hdl.handle.net/10453/126676