Imaging metals in the brain by laser ablation-inductively coupled plasma-mass spectrometry

Hare, DJ; Paul, B; Doble, PA

Imaging metals in the brain by laser ablation-inductively coupled plasma-mass spectrometry

Hare, DJ

Paul, B Doble, PA

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Publication Type:: Chapter
Citation:: Neuromethods, 2017, 124 pp. 33 - 50
Issue Date:: 2017-01-01

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Field	Value	Language
dc.contributor.author	Hare, DJ https://orcid.org/0000-0002-5922-7643	en_US
dc.contributor.author	Paul, B	en_US
dc.contributor.author	Doble, PA https://orcid.org/0000-0002-8472-1301	en_US
dc.date.issued	2017-01-01	en_US
dc.identifier.citation	Neuromethods, 2017, 124 pp. 33 - 50	en_US
dc.identifier.uri	http://hdl.handle.net/10453/126756
dc.description.abstract	© Springer Science+Business Media LLC 2017. Laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) has been an invaluable tool for accurate and precise measurement of metals in geological and environmental samples. However, like many advanced analytical techniques its versatility has seen its translation into several other disciplines, including neuroimaging. In this chapter, we discuss the principles of LA-ICP-MS technology and how it is applied to mesoscale imaging of metals in neurological tissue; evaluate the various approaches available for image construction and analysis; discuss the challenges and opportunities for quantitative metal imaging; and present a selection of applications demonstrating the power of this analytical technique as a tool for assessing both spatial distribution and absolute levels of essential metals in the brain.	en_US
dc.relation.ispartof	Neuromethods	en_US
dc.relation.isbasedon	10.1007/978-1-4939-6918-0_3	en_US
dc.title	Imaging metals in the brain by laser ablation-inductively coupled plasma-mass spectrometry	en_US
dc.type	Chapter
utslib.citation.volume	124	en_US
utslib.for	1109 Neurosciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	124	en_US

Abstract:

© Springer Science+Business Media LLC 2017. Laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) has been an invaluable tool for accurate and precise measurement of metals in geological and environmental samples. However, like many advanced analytical techniques its versatility has seen its translation into several other disciplines, including neuroimaging. In this chapter, we discuss the principles of LA-ICP-MS technology and how it is applied to mesoscale imaging of metals in neurological tissue; evaluate the various approaches available for image construction and analysis; discuss the challenges and opportunities for quantitative metal imaging; and present a selection of applications demonstrating the power of this analytical technique as a tool for assessing both spatial distribution and absolute levels of essential metals in the brain.

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http://hdl.handle.net/10453/126756