Nanostructured calcium phosphates for drug, gene, DNA and protein delivery and as anticancer chemotherapeutic devices

Choi, AH; Macha, IJ; Akyol, S; Cazalbou, S; Ben-Nissan, B

Nanostructured calcium phosphates for drug, gene, DNA and protein delivery and as anticancer chemotherapeutic devices

Choi, AH Macha, IJ Akyol, S Cazalbou, S Ben-Nissan, B

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Publication Type:: Chapter
Citation:: Clinical Applications of Biomaterials: State-of-the-Art Progress, Trends, and Novel Approaches, 2017, pp. 227 - 256
Issue Date:: 2017-06-07

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Field	Value	Language
dc.contributor.author	Choi, AH	en_US
dc.contributor.author	Macha, IJ	en_US
dc.contributor.author	Akyol, S	en_US
dc.contributor.author	Cazalbou, S	en_US
dc.contributor.author	Ben-Nissan, B	en_US
dc.date.issued	2017-06-07	en_US
dc.identifier.citation	Clinical Applications of Biomaterials: State-of-the-Art Progress, Trends, and Novel Approaches, 2017, pp. 227 - 256	en_US
dc.identifier.isbn	9783319560588	en_US
dc.identifier.uri	http://hdl.handle.net/10453/127149
dc.description.abstract	© Springer International Publishing AG 2017. During the past two decades, a number of materials and devices have been utilised in drug delivery applications. A range of biomaterials with different morphologies and pore sizes are currently utilised. For any given biomaterial or bioceramic, having an adequate control of the chemical composition as well as the critical pore sizes is important in terms of controlling the effectiveness when used to deliver drugs locally. In comparison to all currently known and used biomaterials, given the fact that it possesses chemical similarity to human bone, and most importantly its dissolution characteristics which allow for bone regeneration and growth, calcium phosphate holds a special consideration. Moreover, due to their interconnected pore structure, marine materials such as shells and coral exoskeletons show potential for applications in drug delivery due to their easy conversion to calcium phosphates with controllable dissolution rates. This chapter covers a range of current methods used specifically for natural materials that can be converted to calcium phosphates and mixed with polymeric materials as thin film or nanostructured drug, genes, protein and range of delivery and as anticancer chemotherapeutic devices.	en_US
dc.relation.ispartof	Clinical Applications of Biomaterials: State-of-the-Art Progress, Trends, and Novel Approaches	en_US
dc.relation.isbasedon	10.1007/978-3-319-56059-5_6	en_US
dc.title	Nanostructured calcium phosphates for drug, gene, DNA and protein delivery and as anticancer chemotherapeutic devices	en_US
dc.type	Chapter
utslib.for	0699 Other Biological Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US

Abstract:

© Springer International Publishing AG 2017. During the past two decades, a number of materials and devices have been utilised in drug delivery applications. A range of biomaterials with different morphologies and pore sizes are currently utilised. For any given biomaterial or bioceramic, having an adequate control of the chemical composition as well as the critical pore sizes is important in terms of controlling the effectiveness when used to deliver drugs locally. In comparison to all currently known and used biomaterials, given the fact that it possesses chemical similarity to human bone, and most importantly its dissolution characteristics which allow for bone regeneration and growth, calcium phosphate holds a special consideration. Moreover, due to their interconnected pore structure, marine materials such as shells and coral exoskeletons show potential for applications in drug delivery due to their easy conversion to calcium phosphates with controllable dissolution rates. This chapter covers a range of current methods used specifically for natural materials that can be converted to calcium phosphates and mixed with polymeric materials as thin film or nanostructured drug, genes, protein and range of delivery and as anticancer chemotherapeutic devices.

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http://hdl.handle.net/10453/127149