Good guy or bad guy? The duality of wild-type p53 in hormone-dependent breast cancer origin, treatment, and recurrence

McGowan, EM; Lin, Y; Hatoum, D

Good guy or bad guy? The duality of wild-type p53 in hormone-dependent breast cancer origin, treatment, and recurrence

McGowan, EM

Lin, Y

Hatoum, D

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Publication Type:: Journal Article
Citation:: Cancers, 2018, 10 (6)
Issue Date:: 2018-06-01

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Field	Value	Language
dc.contributor.author	McGowan, EM https://orcid.org/0000-0001-6371-3751	en_US
dc.contributor.author	Lin, Y https://orcid.org/0000-0002-4637-9701	en_US
dc.contributor.author	Hatoum, D	en_US
dc.date.available	2018-05-18	en_US
dc.date.issued	2018-06-01	en_US
dc.identifier.citation	Cancers, 2018, 10 (6)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/127284
dc.description.abstract	© 2018 by the authors. Licensee MDPI, Basel, Switzerland. “Lactation is at one point perilously near becoming a cancerous process if it is at all arrested”, Beatson, 1896. Most breast cancers arise from the milk-producing cells that are characterized by aberrant cellular, molecular, and epigenetic translation. By understanding the underlying molecular disruptions leading to the origin of cancer, we might be able to design novel strategies for more efficacious treatments or, ambitiously, divert the cancerous process. It is an established reality that full-term pregnancy in a young woman provides a lifetime reduction in breast cancer risk, whereas delay in full-term pregnancy increases short-term breast cancer risk and the probability of latent breast cancer development. Hormonal activation of the p53 protein (encode by the TP53 gene) in the mammary gland at a critical time in pregnancy has been identified as one of the most important determinants of whether the mammary gland develops latent breast cancer. This review discusses what is known about the protective influence of female hormones in young parous women, with a specific focus on the opportune role of wild-type p53 reprogramming in mammary cell differentiation. The importance of p53 as a protector or perpetrator in hormone-dependent breast cancer, resistance to treatment, and recurrence is also explored.	en_US
dc.relation.ispartof	Cancers	en_US
dc.relation.isbasedon	10.3390/cancers10060172	en_US
dc.title	Good guy or bad guy? The duality of wild-type p53 in hormone-dependent breast cancer origin, treatment, and recurrence	en_US
dc.type	Journal Article
utslib.citation.volume	6	en_US
utslib.citation.volume	10	en_US
utslib.for	1112 Oncology and Carcinogenesis	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Students
utslib.copyright.status	open_access
pubs.issue	6	en_US
pubs.publication-status	Published	en_US
pubs.volume	10	en_US

Abstract:

© 2018 by the authors. Licensee MDPI, Basel, Switzerland. “Lactation is at one point perilously near becoming a cancerous process if it is at all arrested”, Beatson, 1896. Most breast cancers arise from the milk-producing cells that are characterized by aberrant cellular, molecular, and epigenetic translation. By understanding the underlying molecular disruptions leading to the origin of cancer, we might be able to design novel strategies for more efficacious treatments or, ambitiously, divert the cancerous process. It is an established reality that full-term pregnancy in a young woman provides a lifetime reduction in breast cancer risk, whereas delay in full-term pregnancy increases short-term breast cancer risk and the probability of latent breast cancer development. Hormonal activation of the p53 protein (encode by the TP53 gene) in the mammary gland at a critical time in pregnancy has been identified as one of the most important determinants of whether the mammary gland develops latent breast cancer. This review discusses what is known about the protective influence of female hormones in young parous women, with a specific focus on the opportune role of wild-type p53 reprogramming in mammary cell differentiation. The importance of p53 as a protector or perpetrator in hormone-dependent breast cancer, resistance to treatment, and recurrence is also explored.

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http://hdl.handle.net/10453/127284