The Role of Selenium in Neurodegenerative Diseases

Cardoso, BR; Hare, DJ; Bush, AI

The Role of Selenium in Neurodegenerative Diseases

Cardoso, BR Hare, DJ

Bush, AI

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Publication Type:: Chapter
Citation:: Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics, 2017, pp. 35 - 49
Issue Date:: 2017-04-28

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Field	Value	Language
dc.contributor.author	Cardoso, BR	en_US
dc.contributor.author	Hare, DJ https://orcid.org/0000-0002-5922-7643	en_US
dc.contributor.author	Bush, AI	en_US
dc.date.issued	2017-04-28	en_US
dc.identifier.citation	Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics, 2017, pp. 35 - 49	en_US
dc.identifier.isbn	9780128045626	en_US
dc.identifier.uri	http://hdl.handle.net/10453/127319
dc.description.abstract	© 2017 Elsevier Inc. All rights reserved. Selenium is an essential micronutrient, imparting a biological function as a key component of the 21st amino acid, selenocysteine. To date, 25 selenoproteins have been discovered within the human proteome, which can be classified according to a range of functions. Although these proteins are in low abundance in the brain, studies have reported their relevance to normal neurological function, primarily due to antioxidant activity and mechanisms that modulate mitochondrial function. Selenium has also been identified as playing a role in several neurodegenerative disorders, including Alzheimer's and Parkinson's disease, and recent research has suggested possible association with other diseases as multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. This chapter will discuss the emerging role of selenium in neurodegenerative processes, highlighting the rapidly growing interest in this often-overlooked essential element.	en_US
dc.relation.ispartof	Biometals in Neurodegenerative Diseases: Mechanisms and Therapeutics	en_US
dc.relation.isbasedon	10.1016/B978-0-12-804562-6.00003-8	en_US
dc.title	The Role of Selenium in Neurodegenerative Diseases	en_US
dc.type	Chapter
utslib.for	1109 Neurosciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US

Abstract:

© 2017 Elsevier Inc. All rights reserved. Selenium is an essential micronutrient, imparting a biological function as a key component of the 21st amino acid, selenocysteine. To date, 25 selenoproteins have been discovered within the human proteome, which can be classified according to a range of functions. Although these proteins are in low abundance in the brain, studies have reported their relevance to normal neurological function, primarily due to antioxidant activity and mechanisms that modulate mitochondrial function. Selenium has also been identified as playing a role in several neurodegenerative disorders, including Alzheimer's and Parkinson's disease, and recent research has suggested possible association with other diseases as multiple sclerosis, amyotrophic lateral sclerosis, and Huntington's disease. This chapter will discuss the emerging role of selenium in neurodegenerative processes, highlighting the rapidly growing interest in this often-overlooked essential element.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/127319