Spider Venom Peptides

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The Handbook of Biologically Active Peptides, 2006, 1, pp. 369 - 379
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Spider peptide and protein toxins are recognised as highly potent and spefici molecular tools that modulate neurotransmission via interaction with a variety of ion channels, receptors and transporters in vertebrates and invertebrates. The recent discovery of the diversity of thesepeptides means that spider venoms are only now being considered as combinatorial peptide libraries useful for probing synaptic neurotransmission, for validating novel insecticide targets and for aiding in the design of therapeutics and biopesticides. These studies are being greatly assistaed bu the determination of the pharmacophore of these toxins. This review details the discovery, structure and function of these spider venom peptide toxins.
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