The New Kid on the Block: A Specialized Secretion System during Bacterial Sporulation
- Publication Type:
- Journal Article
- Trends in Microbiology, 2018, 26 (8), pp. 663 - 676
- Issue Date:
© 2018 Elsevier Ltd The transport of proteins across the bacterial cell envelope is mediated by protein complexes called specialized secretion systems. These nanomachines exist in both Gram-positive and Gram-negative bacteria and have been categorized into different types based on their structural components and function. Interestingly, multiple studies suggest the existence of a protein complex in endospore-forming bacteria that appears to be a new type of specialized secretion system. This protein complex is called the SpoIIIA-SpoIIQ complex and is an exception to the categorical norm since it appears to be a hybrid composed of different parts from well-defined specialized secretion systems. Here we summarize and discuss the current understanding of this complex and its potential role as a specialized secretion system.
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