The effect of charged groups on protein interactions with poly(HEMA) hydrogels

Elsevier Inc
Publication Type:
Journal Article
Biomaterials, 2006, 27 (4), pp. 567 - 575
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Proteins, lipids and other biomolecules interact strongly with the acrylic-based biomaterials used for contact lenses. Although hydrogels are nominally resistant to protein fouling, many studies have reported considerable amounts of protein bound to poly(2-hydroxyethylmethacrylate) (PHEMA) lenses. This study examined the binding of a series of biomolecules (tear protein analogues, mucin and cholesterol) to poly(methylmethacrylate) (PMMA) and three HEMA-based hydrogels (PHEMA, HEMA plus methacrylic acid (P(HEMAMAA)), HEMA plus methacrylic acid plus N-vinylpyrrolidone (P(HEMAMAANVP))) by use of a quartz crystal microbalance with dissipation (QCM-D) monitoring. The QCM-D estimates changes in the mass and viscous constant for the adsorbed layer through measurements of frequency and dissipation.
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