A guide to integrating immunohistochemistry and chemical imaging

Bishop, DP; Cole, N; Zhang, T; Doble, PA; Hare, DJ

A guide to integrating immunohistochemistry and chemical imaging

Bishop, DP

Cole, N

Zhang, T Doble, PA

Hare, DJ

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Publication Type:: Journal Article
Citation:: Chemical Society Reviews, 2018, 47 (11), pp. 3770 - 3787
Issue Date:: 2018-06-07

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Field	Value	Language
dc.contributor.author	Bishop, DP https://orcid.org/0000-0002-6533-4410	en_US
dc.contributor.author	Cole, N https://orcid.org/0000-0002-9866-4694	en_US
dc.contributor.author	Zhang, T	en_US
dc.contributor.author	Doble, PA https://orcid.org/0000-0002-8472-1301	en_US
dc.contributor.author	Hare, DJ https://orcid.org/0000-0002-5922-7643	en_US
dc.date.issued	2018-06-07	en_US
dc.identifier.citation	Chemical Society Reviews, 2018, 47 (11), pp. 3770 - 3787	en_US
dc.identifier.issn	0306-0012	en_US
dc.identifier.uri	http://hdl.handle.net/10453/128101
dc.description.abstract	© 2018 The Royal Society of Chemistry. Chemical imaging provides new insight into the fundamental atomic, molecular, and biochemical composition of tissue and how they are interrelated in normal physiology. Visualising and quantifying products of pathogenic reactions long before structural changes become apparent also adds a new dimension to understanding disease pathogenesis. While chemical imaging in isolation is somewhat limited by the nature of information it can provide (e.g. peptides, metals, lipids, or functional groups), integrating immunohistochemistry allows simultaneous, targeted imaging of biomolecules while also mapping tissue composition. Together, this approach can provide invaluable information on the inner workings of the cell and the molecular basis of diseases.	en_US
dc.relation	http://purl.org/au-research/grants/arc/DE180100194
dc.relation	http://purl.org/au-research/grants/arc/DP170100036
dc.relation.ispartof	Chemical Society Reviews	en_US
dc.relation.isbasedon	10.1039/c7cs00610a	en_US
dc.subject.classification	General Chemistry	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Metals	en_US
dc.subject.mesh	Lipids	en_US
dc.subject.mesh	Peptides	en_US
dc.subject.mesh	Immunohistochemistry	en_US
dc.subject.mesh	Molecular Imaging	en_US
dc.title	A guide to integrating immunohistochemistry and chemical imaging	en_US
dc.type	Journal Article
utslib.citation.volume	11	en_US
utslib.citation.volume	47	en_US
utslib.for	0304 Medicinal and Biomolecular Chemistry	en_US
utslib.for	03 Chemical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
utslib.copyright.status	open_access
pubs.issue	11	en_US
pubs.publication-status	Published	en_US
pubs.volume	47	en_US

Abstract:

© 2018 The Royal Society of Chemistry. Chemical imaging provides new insight into the fundamental atomic, molecular, and biochemical composition of tissue and how they are interrelated in normal physiology. Visualising and quantifying products of pathogenic reactions long before structural changes become apparent also adds a new dimension to understanding disease pathogenesis. While chemical imaging in isolation is somewhat limited by the nature of information it can provide (e.g. peptides, metals, lipids, or functional groups), integrating immunohistochemistry allows simultaneous, targeted imaging of biomolecules while also mapping tissue composition. Together, this approach can provide invaluable information on the inner workings of the cell and the molecular basis of diseases.

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http://hdl.handle.net/10453/128101