Advances in Nanoporous Anodic Alumina-Based Biosensors to Detect Biomarkers of Clinical Significance: A Review

Rajeev, G; Prieto Simon, B; Marsal, LF; Voelcker, NH

Advances in Nanoporous Anodic Alumina-Based Biosensors to Detect Biomarkers of Clinical Significance: A Review

Rajeev, G Prieto Simon, B Marsal, LF Voelcker, NH

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Publication Type:: Journal Article
Citation:: Advanced Healthcare Materials, 2018, 7 (5)
Issue Date:: 2018-03-07

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Field	Value	Language
dc.contributor.author	Rajeev, G	en_US
dc.contributor.author	Prieto Simon, B	en_US
dc.contributor.author	Marsal, LF	en_US
dc.contributor.author	Voelcker, NH	en_US
dc.date.issued	2018-03-07	en_US
dc.identifier.citation	Advanced Healthcare Materials, 2018, 7 (5)	en_US
dc.identifier.issn	2192-2640	en_US
dc.identifier.uri	http://hdl.handle.net/10453/128205
dc.description.abstract	© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim There is a strong and growing demand for compact, portable, rapid, and low-cost devices to detect biomarkers of interest in clinical and point-of-care diagnostics. Such devices aid in early diagnosis of diseases without the need to rely on expensive and time-consuming large instruments in dedicated laboratories. Over the last decade, numerous biosensors have been developed for detection of a wide range of clinical biomarkers including proteins, nucleic acids, growth factors, and bacterial enzymes. Various transduction techniques have been reported based on biosensor technology that deliver substantial advances in analytical performance, including sensitivity, reproducibility, selectivity, and speed for monitoring a wide range of human health conditions. Nanoporous anodic alumina (NAA) has been used extensively for biosensing applications due to its inherent optical and electrochemical properties, ease of fabrication, large surface area, tunable properties, and high stability in aqueous environment. This review focuses on NAA-based biosensing systems for detection of clinically significant biomarkers using various detection techniques with the main focus being on electrochemical and optical transduction methods. The review covers an overview of the importance of biosensors for biomarkers detection, general (surface and structural) properties and fabrication of NAA, and NAA-based biomarker sensing systems.	en_US
dc.relation.ispartof	Advanced Healthcare Materials	en_US
dc.relation.isbasedon	10.1002/adhm.201700904	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Aluminum Oxide	en_US
dc.subject.mesh	Biosensing Techniques	en_US
dc.subject.mesh	Electrochemical Techniques	en_US
dc.subject.mesh	Nanopores	en_US
dc.subject.mesh	Biomarkers	en_US
dc.title	Advances in Nanoporous Anodic Alumina-Based Biosensors to Detect Biomarkers of Clinical Significance: A Review	en_US
dc.type	Journal Article
utslib.citation.volume	5	en_US
utslib.citation.volume	7	en_US
utslib.for	1004 Medical Biotechnology	en_US
utslib.for	0304 Medicinal and Biomolecular Chemistry	en_US
utslib.for	0903 Biomedical Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	5	en_US
pubs.publication-status	Published	en_US
pubs.volume	7	en_US

Abstract:

© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim There is a strong and growing demand for compact, portable, rapid, and low-cost devices to detect biomarkers of interest in clinical and point-of-care diagnostics. Such devices aid in early diagnosis of diseases without the need to rely on expensive and time-consuming large instruments in dedicated laboratories. Over the last decade, numerous biosensors have been developed for detection of a wide range of clinical biomarkers including proteins, nucleic acids, growth factors, and bacterial enzymes. Various transduction techniques have been reported based on biosensor technology that deliver substantial advances in analytical performance, including sensitivity, reproducibility, selectivity, and speed for monitoring a wide range of human health conditions. Nanoporous anodic alumina (NAA) has been used extensively for biosensing applications due to its inherent optical and electrochemical properties, ease of fabrication, large surface area, tunable properties, and high stability in aqueous environment. This review focuses on NAA-based biosensing systems for detection of clinically significant biomarkers using various detection techniques with the main focus being on electrochemical and optical transduction methods. The review covers an overview of the importance of biosensors for biomarkers detection, general (surface and structural) properties and fabrication of NAA, and NAA-based biomarker sensing systems.

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http://hdl.handle.net/10453/128205