Detection of the suspected neurotoxin β-methylamino-L-alanine (BMAA) in cyanobacterial blooms from multiple water bodies in Eastern Australia

Main, BJ; Bowling, LC; Padula, MP; Bishop, DP; Mitrovic, SM; Guillemin, GJ; Rodgers, KJ

Detection of the suspected neurotoxin β-methylamino-L-alanine (BMAA) in cyanobacterial blooms from multiple water bodies in Eastern Australia

Main, BJ

Bowling, LC

Padula, MP

Bishop, DP

Mitrovic, SM

Guillemin, GJ Rodgers, KJ

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Publication Type:: Journal Article
Citation:: Harmful Algae, 2018, 74 pp. 10 - 18
Issue Date:: 2018-04-01

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Field	Value	Language
dc.contributor.author	Main, BJ https://orcid.org/0000-0003-4719-2444	en_US
dc.contributor.author	Bowling, LC https://orcid.org/0000-0002-0360-0410	en_US
dc.contributor.author	Padula, MP https://orcid.org/0000-0002-8283-0643	en_US
dc.contributor.author	Bishop, DP https://orcid.org/0000-0002-6533-4410	en_US
dc.contributor.author	Mitrovic, SM https://orcid.org/0000-0002-5528-2215	en_US
dc.contributor.author	Guillemin, GJ	en_US
dc.contributor.author	Rodgers, KJ https://orcid.org/0000-0002-3627-9651	en_US
dc.date.available	2018-03-11	en_US
dc.date.issued	2018-04-01	en_US
dc.identifier.citation	Harmful Algae, 2018, 74 pp. 10 - 18	en_US
dc.identifier.issn	1568-9883	en_US
dc.identifier.uri	http://hdl.handle.net/10453/128585
dc.description.abstract	© 2018 The emerging toxin β-methylamino-L-alanine (BMAA) has been linked to the development of a number of neurodegenerative diseases in humans including amyotrophic lateral sclerosis (ALS), Alzheimer's disease, and Parkinson's disease. BMAA has been found to be produced by a range of cyanobacteria, diatoms, and dinoflagellates worldwide, and is present in freshwater, saltwater, and terrestrial ecosystems. Surface scum samples were collected from waterways in rural and urban New South Wales, Australia and algal species identified. Reverse phase liquid chromatography-tandem mass spectrometry was used to analyse sixteen cyanobacterial scum for the presence of BMAA as well as its toxic structural isomer 2,4-diaminobutyric acid (2,4-DAB). BMAA was detected in ten of the samples analysed, and 2,4-DAB in all sixteen. The presence of these toxins in water used for agriculture raises concerns for public health and food security in Australia.	en_US
dc.relation	http://purl.org/au-research/grants/arc/DE180100194
dc.relation.ispartof	Harmful Algae	en_US
dc.relation.isbasedon	10.1016/j.hal.2018.03.004	en_US
dc.subject.classification	Marine Biology & Hydrobiology	en_US
dc.subject.mesh	Cyanobacteria	en_US
dc.subject.mesh	Amino Acids, Diamino	en_US
dc.subject.mesh	Neurotoxins	en_US
dc.subject.mesh	Chromatography, Liquid	en_US
dc.subject.mesh	Fresh Water	en_US
dc.subject.mesh	Environmental Monitoring	en_US
dc.subject.mesh	New South Wales	en_US
dc.subject.mesh	Tandem Mass Spectrometry	en_US
dc.subject.mesh	Harmful Algal Bloom	en_US
dc.title	Detection of the suspected neurotoxin β-methylamino-L-alanine (BMAA) in cyanobacterial blooms from multiple water bodies in Eastern Australia	en_US
dc.type	Journal Article
utslib.citation.volume	74	en_US
utslib.for	0502 Environmental Science and Management	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	05 Environmental Sciences	en_US
utslib.for	06 Biological Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	74	en_US

Abstract:

© 2018 The emerging toxin β-methylamino-L-alanine (BMAA) has been linked to the development of a number of neurodegenerative diseases in humans including amyotrophic lateral sclerosis (ALS), Alzheimer's disease, and Parkinson's disease. BMAA has been found to be produced by a range of cyanobacteria, diatoms, and dinoflagellates worldwide, and is present in freshwater, saltwater, and terrestrial ecosystems. Surface scum samples were collected from waterways in rural and urban New South Wales, Australia and algal species identified. Reverse phase liquid chromatography-tandem mass spectrometry was used to analyse sixteen cyanobacterial scum for the presence of BMAA as well as its toxic structural isomer 2,4-diaminobutyric acid (2,4-DAB). BMAA was detected in ten of the samples analysed, and 2,4-DAB in all sixteen. The presence of these toxins in water used for agriculture raises concerns for public health and food security in Australia.

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http://hdl.handle.net/10453/128585