Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: An emerging need for novel drug delivery systems
Dua, K
Malyla, V
Singhvi, G
Wadhwa, R
Krishna, RV
Shukla, SD
Shastri, MD
Chellappan, DK
Maurya, PK
Satija, S
Mehta, M
Gulati, M
Hansbro, N
Collet, T
Awasthi, R
Gupta, G
Hsu, A
Hansbro, PM
- Publication Type:
- Journal Article
- Citation:
- Chemico-Biological Interactions, 2019, 299 pp. 168 - 178
- Issue Date:
- 2019-02-01
Embargoed
Full metadata record
Field | Value | Language |
---|---|---|
dc.contributor.author |
Dua, K |
en_US |
dc.contributor.author | Malyla, V | en_US |
dc.contributor.author | Singhvi, G | en_US |
dc.contributor.author | Wadhwa, R | en_US |
dc.contributor.author | Krishna, RV | en_US |
dc.contributor.author | Shukla, SD | en_US |
dc.contributor.author | Shastri, MD | en_US |
dc.contributor.author | Chellappan, DK | en_US |
dc.contributor.author | Maurya, PK | en_US |
dc.contributor.author | Satija, S | en_US |
dc.contributor.author | Mehta, M | en_US |
dc.contributor.author | Gulati, M | en_US |
dc.contributor.author | Hansbro, N | en_US |
dc.contributor.author | Collet, T | en_US |
dc.contributor.author | Awasthi, R | en_US |
dc.contributor.author | Gupta, G | en_US |
dc.contributor.author | Hsu, A | en_US |
dc.contributor.author |
Hansbro, PM |
en_US |
dc.date.available | 2018-12-12 | en_US |
dc.date.issued | 2019-02-01 | en_US |
dc.identifier.citation | Chemico-Biological Interactions, 2019, 299 pp. 168 - 178 | en_US |
dc.identifier.issn | 0009-2797 | en_US |
dc.identifier.uri | http://hdl.handle.net/10453/129159 | |
dc.identifier.uri | http://hdl.handle.net/10453/129159 | |
dc.description.abstract | © 2018 Elsevier B.V. Oxidative stress is intensely involved in enhancing the severity of various chronic respiratory diseases (CRDs) including asthma, chronic obstructive pulmonary disease (COPD), infections and lung cancer. Even though there are various existing anti-inflammatory therapies, which are not enough to control the inflammation caused due to various contributing factors such as anti-inflammatory genes and antioxidant enzymes. This leads to an urgent need of novel drug delivery systems to combat the oxidative stress. This review gives a brief insight into the biological factors involved in causing oxidative stress, one of the emerging hallmark feature in CRDs and particularly, highlighting recent trends in various novel drug delivery carriers including microparticles, microemulsions, microspheres, nanoparticles, liposomes, dendrimers, solid lipid nanocarriers etc which can help in combating the oxidative stress in CRDs and ultimately reducing the disease burden and improving the quality of life with CRDs patients. These carriers improve the pharmacokinetics and bioavailability to the target site. However, there is an urgent need for translational studies to validate the drug delivery carriers for clinical administration in the pulmonary clinic. | en_US |
dc.relation.ispartof | Chemico-Biological Interactions | en_US |
dc.relation.isbasedon | 10.1016/j.cbi.2018.12.009 | en_US |
dc.subject.classification | Toxicology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Lung Diseases, Obstructive | en_US |
dc.subject.mesh | Anti-Inflammatory Agents | en_US |
dc.subject.mesh | Liposomes | en_US |
dc.subject.mesh | Emulsions | en_US |
dc.subject.mesh | Drug Delivery Systems | en_US |
dc.subject.mesh | Microspheres | en_US |
dc.subject.mesh | Oxidative Stress | en_US |
dc.subject.mesh | Dendrimers | en_US |
dc.subject.mesh | Nanoparticles | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Lung Diseases, Obstructive | en_US |
dc.subject.mesh | Anti-Inflammatory Agents | en_US |
dc.subject.mesh | Liposomes | en_US |
dc.subject.mesh | Emulsions | en_US |
dc.subject.mesh | Drug Delivery Systems | en_US |
dc.subject.mesh | Microspheres | en_US |
dc.subject.mesh | Oxidative Stress | en_US |
dc.subject.mesh | Dendrimers | en_US |
dc.subject.mesh | Nanoparticles | en_US |
dc.subject.mesh | Anti-Inflammatory Agents | en_US |
dc.subject.mesh | Dendrimers | en_US |
dc.subject.mesh | Drug Delivery Systems | en_US |
dc.subject.mesh | Emulsions | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Liposomes | en_US |
dc.subject.mesh | Lung Diseases, Obstructive | en_US |
dc.subject.mesh | Microspheres | en_US |
dc.subject.mesh | Nanoparticles | en_US |
dc.subject.mesh | Oxidative Stress | en_US |
dc.title | Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: An emerging need for novel drug delivery systems | en_US |
dc.type | Journal Article | |
utslib.description.version | Published | en_US |
utslib.citation.volume | 299 | en_US |
utslib.for | 0601 Biochemistry And Cell Biology | en_US |
pubs.embargo.period | Not known | en_US |
pubs.organisational-group | /University of Technology Sydney | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science | |
pubs.organisational-group | /University of Technology Sydney/Faculty of Science/School of Life Sciences | |
pubs.organisational-group | /University of Technology Sydney/Graduate School of Health | |
utslib.copyright.status | embargoed | |
utslib.copyright.embargo | 2019-12-31T00:00:00+1100 | |
pubs.publication-status | Published | en_US |
pubs.volume | 299 | en_US |
Files in This Item:
Filename | Description | Size | |||
---|---|---|---|---|---|
Dua+et+al_201218.pdf | Accepted manuscript | 1.39 MB | Adobe PDF |
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Abstract:
© 2018 Elsevier B.V. Oxidative stress is intensely involved in enhancing the severity of various chronic respiratory diseases (CRDs) including asthma, chronic obstructive pulmonary disease (COPD), infections and lung cancer. Even though there are various existing anti-inflammatory therapies, which are not enough to control the inflammation caused due to various contributing factors such as anti-inflammatory genes and antioxidant enzymes. This leads to an urgent need of novel drug delivery systems to combat the oxidative stress. This review gives a brief insight into the biological factors involved in causing oxidative stress, one of the emerging hallmark feature in CRDs and particularly, highlighting recent trends in various novel drug delivery carriers including microparticles, microemulsions, microspheres, nanoparticles, liposomes, dendrimers, solid lipid nanocarriers etc which can help in combating the oxidative stress in CRDs and ultimately reducing the disease burden and improving the quality of life with CRDs patients. These carriers improve the pharmacokinetics and bioavailability to the target site. However, there is an urgent need for translational studies to validate the drug delivery carriers for clinical administration in the pulmonary clinic.
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