Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: An emerging need for novel drug delivery systems

Dua, K; Malyla, V; Singhvi, G; Wadhwa, R; Krishna, RV; Shukla, SD; Shastri, MD; Chellappan, DK; Maurya, PK; Satija, S; Mehta, M; Gulati, M; Hansbro, N; Collet, T; Awasthi, R; Gupta, G; Hsu, A; Hansbro, PM

Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: An emerging need for novel drug delivery systems

Malyla, V Singhvi, G Wadhwa, R Krishna, RV Shukla, SD Shastri, MD Chellappan, DK Maurya, PK Satija, S Mehta, M Gulati, M Hansbro, N Collet, T Awasthi, R Gupta, G Hsu, A Hansbro, PM

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Publication Type:: Journal Article
Citation:: Chemico-Biological Interactions, 2019, 299 pp. 168 - 178
Issue Date:: 2019-02-01

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Field	Value	Language
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159	en_US
dc.contributor.author	Malyla, V	en_US
dc.contributor.author	Singhvi, G	en_US
dc.contributor.author	Wadhwa, R	en_US
dc.contributor.author	Krishna, RV	en_US
dc.contributor.author	Shukla, SD	en_US
dc.contributor.author	Shastri, MD	en_US
dc.contributor.author	Chellappan, DK	en_US
dc.contributor.author	Maurya, PK	en_US
dc.contributor.author	Satija, S	en_US
dc.contributor.author	Mehta, M	en_US
dc.contributor.author	Gulati, M	en_US
dc.contributor.author	Hansbro, N	en_US
dc.contributor.author	Collet, T	en_US
dc.contributor.author	Awasthi, R	en_US
dc.contributor.author	Gupta, G	en_US
dc.contributor.author	Hsu, A	en_US
dc.contributor.author	Hansbro, PM https://orcid.org/0000-0002-4741-3035	en_US
dc.date.available	2020-05-25T19:17:08Z
dc.date.issued	2019-02-01	en_US
dc.identifier.citation	Chemico-Biological Interactions, 2019, 299 pp. 168 - 178	en_US
dc.identifier.issn	0009-2797	en_US
dc.identifier.uri	http://hdl.handle.net/10453/129159
dc.description.abstract	© 2018 Elsevier B.V. Oxidative stress is intensely involved in enhancing the severity of various chronic respiratory diseases (CRDs) including asthma, chronic obstructive pulmonary disease (COPD), infections and lung cancer. Even though there are various existing anti-inflammatory therapies, which are not enough to control the inflammation caused due to various contributing factors such as anti-inflammatory genes and antioxidant enzymes. This leads to an urgent need of novel drug delivery systems to combat the oxidative stress. This review gives a brief insight into the biological factors involved in causing oxidative stress, one of the emerging hallmark feature in CRDs and particularly, highlighting recent trends in various novel drug delivery carriers including microparticles, microemulsions, microspheres, nanoparticles, liposomes, dendrimers, solid lipid nanocarriers etc which can help in combating the oxidative stress in CRDs and ultimately reducing the disease burden and improving the quality of life with CRDs patients. These carriers improve the pharmacokinetics and bioavailability to the target site. However, there is an urgent need for translational studies to validate the drug delivery carriers for clinical administration in the pulmonary clinic.	en_US
dc.relation.ispartof	Chemico-Biological Interactions	en_US
dc.relation.isbasedon	10.1016/j.cbi.2018.12.009	en_US
dc.subject.classification	Toxicology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Lung Diseases, Obstructive	en_US
dc.subject.mesh	Anti-Inflammatory Agents	en_US
dc.subject.mesh	Liposomes	en_US
dc.subject.mesh	Emulsions	en_US
dc.subject.mesh	Drug Delivery Systems	en_US
dc.subject.mesh	Microspheres	en_US
dc.subject.mesh	Oxidative Stress	en_US
dc.subject.mesh	Dendrimers	en_US
dc.subject.mesh	Nanoparticles	en_US
dc.title	Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: An emerging need for novel drug delivery systems	en_US
dc.type	Journal Article
utslib.citation.volume	299	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Students
utslib.copyright.status	open_access
pubs.publication-status	Published	en_US
pubs.volume	299	en_US

Abstract:

© 2018 Elsevier B.V. Oxidative stress is intensely involved in enhancing the severity of various chronic respiratory diseases (CRDs) including asthma, chronic obstructive pulmonary disease (COPD), infections and lung cancer. Even though there are various existing anti-inflammatory therapies, which are not enough to control the inflammation caused due to various contributing factors such as anti-inflammatory genes and antioxidant enzymes. This leads to an urgent need of novel drug delivery systems to combat the oxidative stress. This review gives a brief insight into the biological factors involved in causing oxidative stress, one of the emerging hallmark feature in CRDs and particularly, highlighting recent trends in various novel drug delivery carriers including microparticles, microemulsions, microspheres, nanoparticles, liposomes, dendrimers, solid lipid nanocarriers etc which can help in combating the oxidative stress in CRDs and ultimately reducing the disease burden and improving the quality of life with CRDs patients. These carriers improve the pharmacokinetics and bioavailability to the target site. However, there is an urgent need for translational studies to validate the drug delivery carriers for clinical administration in the pulmonary clinic.

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http://hdl.handle.net/10453/129159