Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307

Wyres, KL; Hawkey, J; Hetland, MAK; Fostervold, A; Wick, RR; Judd, LM; Hamidian, M; Howden, BP; Löhr, IH; Holt, KE

Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307

Wyres, KL Hawkey, J Hetland, MAK Fostervold, A Wick, RR Judd, LM Hamidian, M

Howden, BP Löhr, IH Holt, KE

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Publication Type:: Journal Article
Citation:: Journal of Antimicrobial Chemotherapy, 2019, 74 (3), pp. 577 - 581
Issue Date:: 2019-01-01

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Field	Value	Language
dc.contributor.author	Wyres, KL	en_US
dc.contributor.author	Hawkey, J	en_US
dc.contributor.author	Hetland, MAK	en_US
dc.contributor.author	Fostervold, A	en_US
dc.contributor.author	Wick, RR	en_US
dc.contributor.author	Judd, LM	en_US
dc.contributor.author	Hamidian, M https://orcid.org/0000-0002-3614-7261	en_US
dc.contributor.author	Howden, BP	en_US
dc.contributor.author	Löhr, IH	en_US
dc.contributor.author	Holt, KE	en_US
dc.date.available	2018-11-06	en_US
dc.date.issued	2019-01-01	en_US
dc.identifier.citation	Journal of Antimicrobial Chemotherapy, 2019, 74 (3), pp. 577 - 581	en_US
dc.identifier.issn	0305-7453	en_US
dc.identifier.uri	http://hdl.handle.net/10453/129450
dc.description.abstract	© 2019 Oxford University Press. All rights reserved. Objectives: Recent reports indicate the emergence of a new carbapenemase-producing Klebsiella pneumoniae clone, ST307. We sought to better understand the global epidemiology and evolution of this clone and evaluate its association with antimicrobial resistance (AMR) genes. Methods: We collated information from the literature and public databases and performed a comparative analysis of 95 ST307 genomes (including 37 that were newly sequenced). Results: We show that ST307 emerged in the mid-1990s (nearly 20 years prior to its first report), is already globally distributed and is intimately associated with a conserved plasmid harbouring the blaCTX-M-15 ESBL gene and several other AMR determinants. Conclusions: Our findings support the need for enhanced surveillance of this widespread ESBL clone in which carbapenem resistance has occasionally emerged.	en_US
dc.relation.ispartof	Journal of Antimicrobial Chemotherapy	en_US
dc.relation.isbasedon	10.1093/jac/dky492	en_US
dc.subject.classification	Microbiology	en_US
dc.title	Emergence and rapid global dissemination of CTX-M-15-associated Klebsiella pneumoniae strain ST307	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	74	en_US
utslib.for	1108 Medical Microbiology	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	open_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	74	en_US

Abstract:

© 2019 Oxford University Press. All rights reserved. Objectives: Recent reports indicate the emergence of a new carbapenemase-producing Klebsiella pneumoniae clone, ST307. We sought to better understand the global epidemiology and evolution of this clone and evaluate its association with antimicrobial resistance (AMR) genes. Methods: We collated information from the literature and public databases and performed a comparative analysis of 95 ST307 genomes (including 37 that were newly sequenced). Results: We show that ST307 emerged in the mid-1990s (nearly 20 years prior to its first report), is already globally distributed and is intimately associated with a conserved plasmid harbouring the blaCTX-M-15 ESBL gene and several other AMR determinants. Conclusions: Our findings support the need for enhanced surveillance of this widespread ESBL clone in which carbapenem resistance has occasionally emerged.

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http://hdl.handle.net/10453/129450