Mechanisms and management of asthma exacerbations

Ramsahai, JM; Hansbro, PM; Wark, PAB

Mechanisms and management of asthma exacerbations

Ramsahai, JM

Hansbro, PM

Wark, PAB

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Publication Type:: Journal Article
Citation:: American Journal of Respiratory and Critical Care Medicine, 2019, 199 (4), pp. 423 - 432
Issue Date:: 2019-02-15

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Field	Value	Language
dc.contributor.author	Ramsahai, JM https://orcid.org/0000-0002-5164-9374	en_US
dc.contributor.author	Hansbro, PM https://orcid.org/0000-0002-4741-3035	en_US
dc.contributor.author	Wark, PAB	en_US
dc.date.issued	2019-02-15	en_US
dc.identifier.citation	American Journal of Respiratory and Critical Care Medicine, 2019, 199 (4), pp. 423 - 432	en_US
dc.identifier.issn	1073-449X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/129479
dc.description.abstract	Copyright © 2019 by the American Thoracic Society. Acute asthma remains an important medical emergency, the most frequent cause of acute admissions in children and a major source of morbidity for adults with asthma. In all ages with asthma, the presence of exacerbations is an important defining characteristic of asthma severity. In this review, we assess the epidemiology of acute asthma, the triggers of acute exacerbations, and the mechanisms that underlie these exacerbations. We also assess current treatments that prevent exacerbations, with an emphasis on the role of type 2 airway inflammation in the context of acute exacerbations and the novel treatments that effectively target this. Finally we review current mana ement strate ies of the exacerbations themselves	en_US
dc.relation.ispartof	American Journal of Respiratory and Critical Care Medicine	en_US
dc.relation.isbasedon	10.1164/rccm.201810-1931CI	en_US
dc.subject.classification	Respiratory System	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Asthma	en_US
dc.subject.mesh	Acute Disease	en_US
dc.subject.mesh	Anti-Asthmatic Agents	en_US
dc.title	Mechanisms and management of asthma exacerbations	en_US
dc.type	Journal Article
utslib.citation.volume	4	en_US
utslib.citation.volume	199	en_US
utslib.for	1102 Cardiorespiratory Medicine and Haematology	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access
pubs.issue	4	en_US
pubs.publication-status	Published	en_US
pubs.volume	199	en_US

Abstract:

Copyright © 2019 by the American Thoracic Society. Acute asthma remains an important medical emergency, the most frequent cause of acute admissions in children and a major source of morbidity for adults with asthma. In all ages with asthma, the presence of exacerbations is an important defining characteristic of asthma severity. In this review, we assess the epidemiology of acute asthma, the triggers of acute exacerbations, and the mechanisms that underlie these exacerbations. We also assess current treatments that prevent exacerbations, with an emphasis on the role of type 2 airway inflammation in the context of acute exacerbations and the novel treatments that effectively target this. Finally we review current mana ement strate ies of the exacerbations themselves

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http://hdl.handle.net/10453/129479