Mechanisms and management of asthma exacerbations

Publication Type:
Journal Article
American Journal of Respiratory and Critical Care Medicine, 2019, 199 (4), pp. 423 - 432
Issue Date:
Full metadata record
Copyright © 2019 by the American Thoracic Society. Acute asthma remains an important medical emergency, the most frequent cause of acute admissions in children and a major source of morbidity for adults with asthma. In all ages with asthma, the presence of exacerbations is an important defining characteristic of asthma severity. In this review, we assess the epidemiology of acute asthma, the triggers of acute exacerbations, and the mechanisms that underlie these exacerbations. We also assess current treatments that prevent exacerbations, with an emphasis on the role of type 2 airway inflammation in the context of acute exacerbations and the novel treatments that effectively target this. Finally we review current mana ement strate ies of the exacerbations themselves
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