Toxicological characterization of Fukuyoa paulensis (Dinophyceae) from temperate Australia

Larsson, ME; Harwood, TD; Lewis, RJ; Himaya, SWA; Doblin, MA

Toxicological characterization of Fukuyoa paulensis (Dinophyceae) from temperate Australia

Larsson, ME

Harwood, TD Lewis, RJ Himaya, SWA Doblin, MA

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Publication Type:: Journal Article
Citation:: Phycological Research, 2019, 67 (1), pp. 65 - 71
Issue Date:: 2019-01-01

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Field	Value	Language
dc.contributor.author	Larsson, ME https://orcid.org/0000-0003-4310-4582	en_US
dc.contributor.author	Harwood, TD	en_US
dc.contributor.author	Lewis, RJ	en_US
dc.contributor.author	Himaya, SWA	en_US
dc.contributor.author	Doblin, MA https://orcid.org/0000-0001-8750-3433	en_US
dc.date.issued	2019-01-01	en_US
dc.identifier.citation	Phycological Research, 2019, 67 (1), pp. 65 - 71	en_US
dc.identifier.issn	1322-0829	en_US
dc.identifier.uri	http://hdl.handle.net/10453/129601
dc.description.abstract	© 2018 Japanese Society of Phycology Dinoflagellates of the genus Gambierdiscus are known to produce neurotoxins that cause the human illness ciguatera, a tropical and sub-tropical fish poisoning. Some species from the Gambierdiscus genus were recently re-classified into a new genus, Fukuyoa based on their phylogenetic and morphological divergence, however, little is known about their distribution, ecology and toxicology. Here we report the first occurrence of F. paulensis in the temperate coastal waters of eastern Australia and characterize its toxicology. Liquid chromatography–tandem mass spectrometry (LC–MS/MS) did not detect the presence of ciguatoxins, however, a putative maitotoxin congener (MTX-3) was present. Similarly, high maitotoxin-like activity was detected in High Performance Liquid Chromatography (HPLC) fractionated cell extracts using a Ca 2+ influx bioassay on a Fluorescent Imaging Plate Reader (FLIPR), but no ciguatoxin-like activity was detected.	en_US
dc.relation.ispartof	Phycological Research	en_US
dc.relation.isbasedon	10.1111/pre.12349	en_US
dc.subject.classification	Marine Biology & Hydrobiology	en_US
dc.title	Toxicological characterization of Fukuyoa paulensis (Dinophyceae) from temperate Australia	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	67	en_US
utslib.for	0607 Plant Biology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - C3 - Climate Change Cluster
utslib.copyright.status	closed_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	67	en_US

Abstract:

© 2018 Japanese Society of Phycology Dinoflagellates of the genus Gambierdiscus are known to produce neurotoxins that cause the human illness ciguatera, a tropical and sub-tropical fish poisoning. Some species from the Gambierdiscus genus were recently re-classified into a new genus, Fukuyoa based on their phylogenetic and morphological divergence, however, little is known about their distribution, ecology and toxicology. Here we report the first occurrence of F. paulensis in the temperate coastal waters of eastern Australia and characterize its toxicology. Liquid chromatography–tandem mass spectrometry (LC–MS/MS) did not detect the presence of ciguatoxins, however, a putative maitotoxin congener (MTX-3) was present. Similarly, high maitotoxin-like activity was detected in High Performance Liquid Chromatography (HPLC) fractionated cell extracts using a Ca 2+ influx bioassay on a Fluorescent Imaging Plate Reader (FLIPR), but no ciguatoxin-like activity was detected.

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http://hdl.handle.net/10453/129601