Development of ciprofloxacin-loaded poly(vinyl alcohol) dry powder formulations for lung delivery

Silva, DM; Paleco, R; Traini, D; Sencadas, V

Development of ciprofloxacin-loaded poly(vinyl alcohol) dry powder formulations for lung delivery

Silva, DM Paleco, R Traini, D Sencadas, V

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Publication Type:: Journal Article
Citation:: International Journal of Pharmaceutics, 2018, 547 (1-2), pp. 114 - 121
Issue Date:: 2018-08-25

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Field	Value	Language
dc.contributor.author	Silva, DM	en_US
dc.contributor.author	Paleco, R	en_US
dc.contributor.author	Traini, D	en_US
dc.contributor.author	Sencadas, V	en_US
dc.date.available	2018-05-23	en_US
dc.date.issued	2018-08-25	en_US
dc.identifier.citation	International Journal of Pharmaceutics, 2018, 547 (1-2), pp. 114 - 121	en_US
dc.identifier.issn	0378-5173	en_US
dc.identifier.uri	http://hdl.handle.net/10453/129689
dc.description.abstract	© 2018 Elsevier B.V. Polymeric microparticles are micro carriers for the sustained drug delivery of drugs in the lungs, used as alternatives to the use of established excipients. This study aims to develop and characterize inhalable ciprofloxacin (CPx)-loaded poly(vinyl alcohol) (PVA) microparticles by a single-step spray-drying procedure. The optimization of the processing parameters was achieved by an orthogonal design of the most relevant processing parameters (polymer concentration, feed rate and inlet temperature). The obtained spray-dried particles showed a drug encapsulation efficiency higher than 90%. Furthermore, PVA-CPx formulations, with drug contents up to 10 wt%, showed a morphology and size suitable for inhalation, with a sustained release profile over 24 h. Data from Fourier transformed infra-red spectroscopy and differential scanning calorimetry indicated absence of interaction between the polymer matrix and the drug. Aerodynamic assessment of PVA-CPx 10 wt% was determined by the next generation impactor (NGI), using spray-dried CPx as a control. The results showed improved values of mass median aerodynamic diameter (5.06±0.10μm) and a fine particle fraction (39.78±0.98%) when comparing with the CPx alone (5.33±0.39μm and 30.43±1.38%). This study highlights the potential of spray-dried PVA microparticles as drug carriers for lung local delivery of antibiotics.	en_US
dc.relation.ispartof	International Journal of Pharmaceutics	en_US
dc.relation.isbasedon	10.1016/j.ijpharm.2018.05.060	en_US
dc.subject.classification	Pharmacology & Pharmacy	en_US
dc.subject.mesh	Lung	en_US
dc.subject.mesh	Polyvinyl Alcohol	en_US
dc.subject.mesh	Ciprofloxacin	en_US
dc.subject.mesh	Drug Carriers	en_US
dc.subject.mesh	Powders	en_US
dc.subject.mesh	Anti-Bacterial Agents	en_US
dc.subject.mesh	Calorimetry, Differential Scanning	en_US
dc.subject.mesh	Desiccation	en_US
dc.subject.mesh	Thermogravimetry	en_US
dc.subject.mesh	Administration, Inhalation	en_US
dc.subject.mesh	Chemistry, Pharmaceutical	en_US
dc.subject.mesh	Particle Size	en_US
dc.subject.mesh	Dry Powder Inhalers	en_US
dc.title	Development of ciprofloxacin-loaded poly(vinyl alcohol) dry powder formulations for lung delivery	en_US
dc.type	Journal Article
utslib.citation.volume	1-2	en_US
utslib.citation.volume	547	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	closed_access
pubs.issue	1-2	en_US
pubs.publication-status	Published	en_US
pubs.volume	547	en_US

Abstract:

© 2018 Elsevier B.V. Polymeric microparticles are micro carriers for the sustained drug delivery of drugs in the lungs, used as alternatives to the use of established excipients. This study aims to develop and characterize inhalable ciprofloxacin (CPx)-loaded poly(vinyl alcohol) (PVA) microparticles by a single-step spray-drying procedure. The optimization of the processing parameters was achieved by an orthogonal design of the most relevant processing parameters (polymer concentration, feed rate and inlet temperature). The obtained spray-dried particles showed a drug encapsulation efficiency higher than 90%. Furthermore, PVA-CPx formulations, with drug contents up to 10 wt%, showed a morphology and size suitable for inhalation, with a sustained release profile over 24 h. Data from Fourier transformed infra-red spectroscopy and differential scanning calorimetry indicated absence of interaction between the polymer matrix and the drug. Aerodynamic assessment of PVA-CPx 10 wt% was determined by the next generation impactor (NGI), using spray-dried CPx as a control. The results showed improved values of mass median aerodynamic diameter (5.06±0.10μm) and a fine particle fraction (39.78±0.98%) when comparing with the CPx alone (5.33±0.39μm and 30.43±1.38%). This study highlights the potential of spray-dried PVA microparticles as drug carriers for lung local delivery of antibiotics.

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http://hdl.handle.net/10453/129689