Extensively drug-resistant ArmA-producing acinetobacter baumannii in an Italian intensive care unit

Caio, C; Maugeri, G; Zingali, T; Gona, F; Stefani, S; Mezzatesta, ML

Extensively drug-resistant ArmA-producing acinetobacter baumannii in an Italian intensive care unit

Caio, C Maugeri, G Zingali, T

Gona, F Stefani, S Mezzatesta, ML

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Publication Type:: Journal Article
Citation:: New Microbiologica, 2018, 41 (2), pp. 159 - 161
Issue Date:: 2018-04-01

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Field	Value	Language
dc.contributor.author	Caio, C	en_US
dc.contributor.author	Maugeri, G	en_US
dc.contributor.author	Zingali, T https://orcid.org/0000-0002-1526-1823	en_US
dc.contributor.author	Gona, F	en_US
dc.contributor.author	Stefani, S	en_US
dc.contributor.author	Mezzatesta, ML	en_US
dc.date.available	2018-05-28	en_US
dc.date.issued	2018-04-01	en_US
dc.identifier.citation	New Microbiologica, 2018, 41 (2), pp. 159 - 161	en_US
dc.identifier.issn	1121-7138	en_US
dc.identifier.uri	http://hdl.handle.net/10453/130337
dc.description.abstract	© 2018 by EDIMES - Edizioni Internazionali Srl. All rights reserved. We describe the spread of 12 carbapenem-resistant Acinetobacter baumannii isolates in hospitalized patients. All strains showed an extensively drug-resistant phenotype and high-level of aminoglycoside resistance, harboring the ArmA gene and blaoxa-23 downstream of ISAba1 (transposon Tn2008 arrangement) where both were located on the chromosome. These strains carry a class 1 integron containing the gene cassette aacA4-catB8-aadA1. Molecular analysis revealed that all isolates belonged to the same sequence type (ST) 2 clone. The spread of ArmA-producing A. baumannii strains limit the treatment options showing the dramatic situation which requires novel therapies to limit high mortality rates.	en_US
dc.relation.ispartof	New Microbiologica	en_US
dc.subject.classification	Microbiology	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Acinetobacter baumannii	en_US
dc.subject.mesh	Acinetobacter Infections	en_US
dc.subject.mesh	Cross Infection	en_US
dc.subject.mesh	Carbapenems	en_US
dc.subject.mesh	Bacterial Proteins	en_US
dc.subject.mesh	Anti-Bacterial Agents	en_US
dc.subject.mesh	Microbial Sensitivity Tests	en_US
dc.subject.mesh	Drug Resistance, Multiple, Bacterial	en_US
dc.subject.mesh	Intensive Care Units	en_US
dc.subject.mesh	Italy	en_US
dc.title	Extensively drug-resistant ArmA-producing acinetobacter baumannii in an Italian intensive care unit	en_US
dc.type	Journal Article
utslib.citation.volume	2	en_US
utslib.citation.volume	41	en_US
utslib.for	1108 Medical Microbiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Students
utslib.copyright.status	closed_access
pubs.issue	2	en_US
pubs.publication-status	Published	en_US
pubs.volume	41	en_US

Abstract:

© 2018 by EDIMES - Edizioni Internazionali Srl. All rights reserved. We describe the spread of 12 carbapenem-resistant Acinetobacter baumannii isolates in hospitalized patients. All strains showed an extensively drug-resistant phenotype and high-level of aminoglycoside resistance, harboring the ArmA gene and blaoxa-23 downstream of ISAba1 (transposon Tn2008 arrangement) where both were located on the chromosome. These strains carry a class 1 integron containing the gene cassette aacA4-catB8-aadA1. Molecular analysis revealed that all isolates belonged to the same sequence type (ST) 2 clone. The spread of ArmA-producing A. baumannii strains limit the treatment options showing the dramatic situation which requires novel therapies to limit high mortality rates.

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http://hdl.handle.net/10453/130337