Extranuclear signaling by sex steroid receptors and clinical implications in breast cancer

Boonyaratanakornkit, V; Hamilton, N; Márquez-Garbán, DC; Pateetin, P; McGowan, EM; Pietras, RJ

Extranuclear signaling by sex steroid receptors and clinical implications in breast cancer

Boonyaratanakornkit, V Hamilton, N Márquez-Garbán, DC Pateetin, P McGowan, EM

Pietras, RJ

Permalink

Publication Type:: Journal Article
Citation:: Molecular and Cellular Endocrinology, 2018, 466 pp. 51 - 72
Issue Date:: 2018-05-05

Closed Access

	Filename	Description	Size
	1-s2.0-S0303720717305750-main.pdf	Published Version	2.7 MB	Adobe PDF	View/Open

Copyright Clearance Process

Recently Added
In Progress
Closed Access

This item is closed access and not available.

Full metadata record

Field	Value	Language
dc.contributor.author	Boonyaratanakornkit, V	en_US
dc.contributor.author	Hamilton, N	en_US
dc.contributor.author	Márquez-Garbán, DC	en_US
dc.contributor.author	Pateetin, P	en_US
dc.contributor.author	McGowan, EM https://orcid.org/0000-0001-6371-3751	en_US
dc.contributor.author	Pietras, RJ	en_US
dc.date.available	2017-11-13	en_US
dc.date.issued	2018-05-05	en_US
dc.identifier.citation	Molecular and Cellular Endocrinology, 2018, 466 pp. 51 - 72	en_US
dc.identifier.issn	0303-7207	en_US
dc.identifier.uri	http://hdl.handle.net/10453/130341
dc.description.abstract	© 2017 Elsevier B.V. Estrogen and progesterone play essential roles in the development and progression of breast cancer. Over 70% of breast cancers express estrogen receptors (ER) and progesterone receptors (PR), emphasizing the need for better understanding of ER and PR signaling. ER and PR are traditionally viewed as transcription factors that directly bind DNA to regulate gene networks. In addition to nuclear signaling, ER and PR mediate hormone-induced, rapid extranuclear signaling at the cell membrane or in the cytoplasm which triggers downstream signaling to regulate rapid or extended cellular responses. Specialized membrane and cytoplasmic proteins may also initiate hormone-induced extranuclear signaling. Rapid extranuclear signaling converges with its nuclear counterpart to amplify ER/PR transcription and specify gene regulatory networks. This review summarizes current understanding and updates on ER and PR extranuclear signaling. Further investigation of ER/PR extranuclear signaling may lead to development of novel targeted therapeutics for breast cancer management.	en_US
dc.relation.ispartof	Molecular and Cellular Endocrinology	en_US
dc.relation.isbasedon	10.1016/j.mce.2017.11.010	en_US
dc.subject.classification	Endocrinology & Metabolism	en_US
dc.subject.mesh	Breast	en_US
dc.subject.mesh	Cell Line, Tumor	en_US
dc.subject.mesh	Cell Membrane	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Mice	en_US
dc.subject.mesh	Breast Neoplasms	en_US
dc.subject.mesh	Membrane Proteins	en_US
dc.subject.mesh	Receptors, Estrogen	en_US
dc.subject.mesh	Receptors, Progesterone	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Gene Knockout Techniques	en_US
dc.title	Extranuclear signaling by sex steroid receptors and clinical implications in breast cancer	en_US
dc.type	Journal Article
utslib.citation.volume	466	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
utslib.for	1112 Oncology and Carcinogenesis	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	07 Agricultural and Veterinary Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Engineering and Information Technology
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	466	en_US

Abstract:

© 2017 Elsevier B.V. Estrogen and progesterone play essential roles in the development and progression of breast cancer. Over 70% of breast cancers express estrogen receptors (ER) and progesterone receptors (PR), emphasizing the need for better understanding of ER and PR signaling. ER and PR are traditionally viewed as transcription factors that directly bind DNA to regulate gene networks. In addition to nuclear signaling, ER and PR mediate hormone-induced, rapid extranuclear signaling at the cell membrane or in the cytoplasm which triggers downstream signaling to regulate rapid or extended cellular responses. Specialized membrane and cytoplasmic proteins may also initiate hormone-induced extranuclear signaling. Rapid extranuclear signaling converges with its nuclear counterpart to amplify ER/PR transcription and specify gene regulatory networks. This review summarizes current understanding and updates on ER and PR extranuclear signaling. Further investigation of ER/PR extranuclear signaling may lead to development of novel targeted therapeutics for breast cancer management.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/130341