Inferring action-dependent outcome representations depends on anterior but not posterior medial orbitofrontal cortex

Bradfield, LA; Hart, G; Balleine, BW

Inferring action-dependent outcome representations depends on anterior but not posterior medial orbitofrontal cortex

Bradfield, LA

Hart, G Balleine, BW

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Publication Type:: Journal Article
Citation:: Neurobiology of Learning and Memory, 2018, 155 pp. 463 - 473
Issue Date:: 2018-11-01

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Field	Value	Language
dc.contributor.author	Bradfield, LA https://orcid.org/0000-0003-3921-0745	en_US
dc.contributor.author	Hart, G	en_US
dc.contributor.author	Balleine, BW	en_US
dc.date.available	2018-09-19	en_US
dc.date.issued	2018-11-01	en_US
dc.identifier.citation	Neurobiology of Learning and Memory, 2018, 155 pp. 463 - 473	en_US
dc.identifier.issn	1074-7427	en_US
dc.identifier.uri	http://hdl.handle.net/10453/130607
dc.description.abstract	© 2018 Elsevier Inc. Although studies examining orbitofrontal cortex (OFC) often treat it as though it were functionally homogeneous, recent evidence has questioned this assumption. Not only are the various subregions of OFC (lateral, ventral, and medial) hetereogeneous, but there is further evidence of heterogeneity within those subregions. For example, several studies in both humans and monkeys have revealed a functional subdivision along the anterior-posterior gradient of the medial OFC (mOFC). Given our previous findings suggesting that, in rats, the mOFC is responsible for inferring the likelihood of unobservable action outcomes (Bradfield, Dezfouli, van Holstein, Chieng, & Balleine, 2015), and given the anterior nature of the placements of our prior manipulations, we decided to assess whether the rat mOFC also differs in connection and function along its anteroposterior axis. We first used retrograde tracing to compare the density of efferents from mOFC to several structures known to contribute to goal-directed action: the mediodorsal thalamus, basolateral amygdala, posterior dorsomedial striatum, nucleus accumbens core and ventral tegmental area. We then compared the functional effects of anterior versus posterior mOFC excitotoxic lesions on tests of Pavlovian-instrumental transfer, instrumental outcome devaluation and outcome-specific reinstatement. We found evidence that the anterior mOFC had greater connectivity with the accumbens core and greater functional involvement in goal-directed action than the posterior mOFC. Consistent with previous findings across species, therefore, these results suggest that the anterior and posterior mOFC of the rat are indeed functionally distinct, and that it is the anterior mOFC that is particularly critical for inferring unobservable action outcomes.	en_US
dc.relation.ispartof	Neurobiology of Learning and Memory	en_US
dc.relation.isbasedon	10.1016/j.nlm.2018.09.008	en_US
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	Behavioral Science & Comparative Psychology	en_US
dc.subject.mesh	Brain	en_US
dc.subject.mesh	Prefrontal Cortex	en_US
dc.subject.mesh	Neural Pathways	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Rats, Long-Evans	en_US
dc.subject.mesh	Behavior, Animal	en_US
dc.subject.mesh	Association Learning	en_US
dc.subject.mesh	Conditioning (Psychology)	en_US
dc.subject.mesh	Conditioning, Classical	en_US
dc.subject.mesh	Conditioning, Operant	en_US
dc.subject.mesh	Psychomotor Performance	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Extinction, Psychological	en_US
dc.subject.mesh	Conditioning, Psychological	en_US
dc.title	Inferring action-dependent outcome representations depends on anterior but not posterior medial orbitofrontal cortex	en_US
dc.type	Journal Article
utslib.citation.volume	155	en_US
utslib.for	1109 Neurosciences	en_US
utslib.for	1702 Cognitive Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
utslib.for	17 Psychology and Cognitive Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access	*
pubs.publication-status	Published	en_US
pubs.volume	155	en_US

Abstract:

© 2018 Elsevier Inc. Although studies examining orbitofrontal cortex (OFC) often treat it as though it were functionally homogeneous, recent evidence has questioned this assumption. Not only are the various subregions of OFC (lateral, ventral, and medial) hetereogeneous, but there is further evidence of heterogeneity within those subregions. For example, several studies in both humans and monkeys have revealed a functional subdivision along the anterior-posterior gradient of the medial OFC (mOFC). Given our previous findings suggesting that, in rats, the mOFC is responsible for inferring the likelihood of unobservable action outcomes (Bradfield, Dezfouli, van Holstein, Chieng, & Balleine, 2015), and given the anterior nature of the placements of our prior manipulations, we decided to assess whether the rat mOFC also differs in connection and function along its anteroposterior axis. We first used retrograde tracing to compare the density of efferents from mOFC to several structures known to contribute to goal-directed action: the mediodorsal thalamus, basolateral amygdala, posterior dorsomedial striatum, nucleus accumbens core and ventral tegmental area. We then compared the functional effects of anterior versus posterior mOFC excitotoxic lesions on tests of Pavlovian-instrumental transfer, instrumental outcome devaluation and outcome-specific reinstatement. We found evidence that the anterior mOFC had greater connectivity with the accumbens core and greater functional involvement in goal-directed action than the posterior mOFC. Consistent with previous findings across species, therefore, these results suggest that the anterior and posterior mOFC of the rat are indeed functionally distinct, and that it is the anterior mOFC that is particularly critical for inferring unobservable action outcomes.

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http://hdl.handle.net/10453/130607