Survey of the Allelic Frequency of a NOS2A Promoter Microsatellite in Human Populations: Assessment of the NOS2A Gene and Predisposition to Infectious Disease

Publisher:
Academic Press Inc
Publication Type:
Journal Article
Citation:
Nitric Oxide-Biology And Chemistry, 2000, 4 (4), pp. 379 - 383
Issue Date:
2000-01
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Allelic frequencies of a (CCTTT) n pentanucleotide repeat in the NOS2A promoter region were determined in a total of 1393 unrelated individuals from five specific population groups in four continents: Africa, Europe, Asia, and the Caribbean. There were highly significant differences in allele frequencies between the ethnically diverse populations. The repeat variation may have implications for the selective pressure of malaria or other infectious diseases that may operate at the NOS2 locus.
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