Recent advances in functional nanomaterials for light–triggered cancer therapy

Gai, S; Yang, G; Yang, P; He, F; Lin, J; Jin, D; Xing, B

Recent advances in functional nanomaterials for light–triggered cancer therapy

Gai, S Yang, G Yang, P He, F Lin, J Jin, D

Xing, B

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Publication Type:: Journal Article
Citation:: Nano Today, 2018, 19 pp. 146 - 187
Issue Date:: 2018-04-01

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Field	Value	Language
dc.contributor.author	Gai, S	en_US
dc.contributor.author	Yang, G	en_US
dc.contributor.author	Yang, P	en_US
dc.contributor.author	He, F	en_US
dc.contributor.author	Lin, J	en_US
dc.contributor.author	Jin, D https://orcid.org/0000-0003-1046-2666	en_US
dc.contributor.author	Xing, B	en_US
dc.date.issued	2018-04-01	en_US
dc.identifier.citation	Nano Today, 2018, 19 pp. 146 - 187	en_US
dc.identifier.issn	1748-0132	en_US
dc.identifier.uri	http://hdl.handle.net/10453/130957
dc.description.abstract	© 2018 Elsevier Ltd Photo–triggered therapeutic modalities for cancer have attracted enormous attention in recent years due to the easily focused and tuned properties of irradiation light that enable the localized treatment with non–invasive, direct and accurate characteristics. In addition, by using new developed functional nanomaterials, different therapeutic modalities can be integrated into a single platform, and co–therapies with dramatically enhanced anti–cancer ability by synergetic therapeutic effects are obtained. In the view of the fast development of anti–cancer strategy, we present an in–depth review of major breakthroughs in recent advanced functional nanomaterials for photo–triggered therapy. This review first summarizes the organic and inorganic photosensitizers for photodynamic therapy (PDT), four kinds of photothermal materials for photothermal therapy (PTT), as well as photo–switchable molecules or photolabile chemical groups bonded materials for chemotherapy. For each part, the therapeutic materials, mechanisms, superiorities and typical representatives are examined extensively. Then, we systematically discuss the optimized multifunctional nanomaterials consist of the above materials for PTT/PDT co–therapy, PTT/chemo co–therapy, PDT/chemo co–therapy and radiotherapy–composed co–therapy etc. And the synergetic therapeutic mechanism, anti–cancer efficiency, safety and design of therapeutic materials are highlighted. Finally, we give an outlook of the future directions of the rapidly growing functional nanomaterials for photo–triggered therapy, and propose several associated challenges and potential solutions.	en_US
dc.relation.ispartof	Nano Today	en_US
dc.relation.isbasedon	10.1016/j.nantod.2018.02.010	en_US
dc.subject.classification	Nanoscience & Nanotechnology	en_US
dc.title	Recent advances in functional nanomaterials for light–triggered cancer therapy	en_US
dc.type	Journal Article
utslib.citation.volume	19	en_US
utslib.for	1112 Oncology and Carcinogenesis	en_US
utslib.for	1007 Nanotechnology	en_US
utslib.for	0903 Biomedical Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	19	en_US

Abstract:

© 2018 Elsevier Ltd Photo–triggered therapeutic modalities for cancer have attracted enormous attention in recent years due to the easily focused and tuned properties of irradiation light that enable the localized treatment with non–invasive, direct and accurate characteristics. In addition, by using new developed functional nanomaterials, different therapeutic modalities can be integrated into a single platform, and co–therapies with dramatically enhanced anti–cancer ability by synergetic therapeutic effects are obtained. In the view of the fast development of anti–cancer strategy, we present an in–depth review of major breakthroughs in recent advanced functional nanomaterials for photo–triggered therapy. This review first summarizes the organic and inorganic photosensitizers for photodynamic therapy (PDT), four kinds of photothermal materials for photothermal therapy (PTT), as well as photo–switchable molecules or photolabile chemical groups bonded materials for chemotherapy. For each part, the therapeutic materials, mechanisms, superiorities and typical representatives are examined extensively. Then, we systematically discuss the optimized multifunctional nanomaterials consist of the above materials for PTT/PDT co–therapy, PTT/chemo co–therapy, PDT/chemo co–therapy and radiotherapy–composed co–therapy etc. And the synergetic therapeutic mechanism, anti–cancer efficiency, safety and design of therapeutic materials are highlighted. Finally, we give an outlook of the future directions of the rapidly growing functional nanomaterials for photo–triggered therapy, and propose several associated challenges and potential solutions.

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http://hdl.handle.net/10453/130957