Systematic investigation of functional ligands for colloidal stable upconversion nanoparticles†

Duong, HTT; Chen, Y; Tawfik, SA; Wen, S; Parviz, M; Shimoni, O; Ab, DJ

Systematic investigation of functional ligands for colloidal stable upconversion nanoparticles†

Duong, HTT

Chen, Y

Tawfik, SA

Wen, S

Parviz, M

Shimoni, O

Ab, DJ

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Publication Type:: Journal Article
Citation:: RSC Advances, 2018, 8 (9), pp. 4842 - 4849
Issue Date:: 2018-01-01

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Field	Value	Language
dc.contributor.author	Duong, HTT https://orcid.org/0000-0003-2224-2046	en_US
dc.contributor.author	Chen, Y https://orcid.org/0000-0002-7886-7144	en_US
dc.contributor.author	Tawfik, SA https://orcid.org/0000-0003-3592-1419	en_US
dc.contributor.author	Wen, S https://orcid.org/0000-0002-4670-4658	en_US
dc.contributor.author	Parviz, M https://orcid.org/0000-0002-0696-9205	en_US
dc.contributor.author	Shimoni, O https://orcid.org/0000-0001-8822-1024	en_US
dc.contributor.author	Ab, DJ https://orcid.org/0000-0003-1046-2666	en_US
dc.date.issued	2018-01-01	en_US
dc.identifier.citation	RSC Advances, 2018, 8 (9), pp. 4842 - 4849	en_US
dc.identifier.uri	http://hdl.handle.net/10453/131033
dc.description.abstract	© The Royal Society of Chemistry 2018. Despite intense efforts on surface functionalization to generate hydrophilic upconversion nanoparticles (UCNPs), long-term colloidal stability in physiological buffers remains a major concern. Here we quantitatively investigate the competitive adsorption of phosphate, carboxylic acid and sulphonic acid onto the surface of UCNPs and study their binding strength to identify the best conjugation strategy. To achieve this, we designed and synthesized three di-block copolymers composed of poly(ethylene glycol) methyl ether acrylate and a polymer block bearing phosphate, carboxylic or sulphonic acid anchoring groups prepared by an advanced polymerization technique, Reversible Addition Fragmentation Chain Transfer (RAFT). Analytical tools provide the evidence that phosphate ligands completely replaced all the oleic acid capping molecules on the surface of the UCNPs compared with incomplete ligand exchange by carboxylic and sulphonic acid groups. Meanwhile, simulated quantitative adsorption energy measurements confirmed that among the three functional groups, the calculated adsorption strength for phosphate anchoring ligands is higher which is in good agreement with experimental results regarding the best colloidal stability, especially in phosphate buffer solution. This finding suggests that polymers with multiple anchoring negatively charged phosphate moieties provide excellent colloidal stability for lanthanide ion-doped luminescent nanoparticles for various potential applications.	en_US
dc.relation	http://purl.org/au-research/grants/arc/IH150100028
dc.relation	http://purl.org/au-research/grants/nhmrc/APP1101258
dc.relation	http://purl.org/au-research/grants/arc/FT130100517
dc.relation.ispartof	RSC Advances	en_US
dc.relation.isbasedon	10.1039/c7ra13765f	en_US
dc.title	Systematic investigation of functional ligands for colloidal stable upconversion nanoparticles†	en_US
dc.type	Journal Article
utslib.citation.volume	9	en_US
utslib.citation.volume	8	en_US
utslib.for	1007 Nanotechnology	en_US
utslib.for	0301 Analytical Chemistry	en_US
utslib.for	03 Chemical Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	open_access
pubs.issue	9	en_US
pubs.publication-status	Published	en_US
pubs.volume	8	en_US

Abstract:

© The Royal Society of Chemistry 2018. Despite intense efforts on surface functionalization to generate hydrophilic upconversion nanoparticles (UCNPs), long-term colloidal stability in physiological buffers remains a major concern. Here we quantitatively investigate the competitive adsorption of phosphate, carboxylic acid and sulphonic acid onto the surface of UCNPs and study their binding strength to identify the best conjugation strategy. To achieve this, we designed and synthesized three di-block copolymers composed of poly(ethylene glycol) methyl ether acrylate and a polymer block bearing phosphate, carboxylic or sulphonic acid anchoring groups prepared by an advanced polymerization technique, Reversible Addition Fragmentation Chain Transfer (RAFT). Analytical tools provide the evidence that phosphate ligands completely replaced all the oleic acid capping molecules on the surface of the UCNPs compared with incomplete ligand exchange by carboxylic and sulphonic acid groups. Meanwhile, simulated quantitative adsorption energy measurements confirmed that among the three functional groups, the calculated adsorption strength for phosphate anchoring ligands is higher which is in good agreement with experimental results regarding the best colloidal stability, especially in phosphate buffer solution. This finding suggests that polymers with multiple anchoring negatively charged phosphate moieties provide excellent colloidal stability for lanthanide ion-doped luminescent nanoparticles for various potential applications.

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http://hdl.handle.net/10453/131033