Analysis of amphetamine-type substances by capillary zone electrophoresis using capacitively coupled contactless conductivity detection

Publication Type:
Journal Article
Citation:
Electrophoresis, 2010, 31 (15), pp. 2608 - 2613
Issue Date:
2010-08-01
Metrics:
Full metadata record
Files in This Item:
Filename Description Size
Thumbnail2009007081OK.pdf383.72 kB
Adobe PDF
CE with capacitively coupled contactless conductivity detection (C 4D) was employed for the separation and detection of seven amphetamine analogues as well as amphetamine, dextroamphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine. The separation electrolyte was 30 mM hydroxypropyl-β-cyclodextrin (HPβCD) in a 75 mM acetic acid+25 mM sodium acetate buffer adjusted to pH 4.55. Conductivity detection was compared with UV detection using this same electrolyte. Average detection limits for C 4D and UV were 1.3 and 1.0 ppm, respectively. The effects of HPβCD concentration and BGE composition on the selectivity of the separation were also investigated. An illicit, street-grade sample of 3,4-methylenedioxymethamphetamine (Ecstasy) and a prescription dextroamphetamine tablet were also analysed. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
Please use this identifier to cite or link to this item: