Analysis of amphetamine-type substances by capillary zone electrophoresis using capacitively coupled contactless conductivity detection

Publication Type:
Journal Article
Electrophoresis, 2010, 31 (15), pp. 2608 - 2613
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CE with capacitively coupled contactless conductivity detection (C 4D) was employed for the separation and detection of seven amphetamine analogues as well as amphetamine, dextroamphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine. The separation electrolyte was 30 mM hydroxypropyl-β-cyclodextrin (HPβCD) in a 75 mM acetic acid+25 mM sodium acetate buffer adjusted to pH 4.55. Conductivity detection was compared with UV detection using this same electrolyte. Average detection limits for C 4D and UV were 1.3 and 1.0 ppm, respectively. The effects of HPβCD concentration and BGE composition on the selectivity of the separation were also investigated. An illicit, street-grade sample of 3,4-methylenedioxymethamphetamine (Ecstasy) and a prescription dextroamphetamine tablet were also analysed. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.
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