Interactions with the macrophages: An emerging targeted approach using novel drug delivery systems in respiratory diseases

Mehta, M; Deeksha; Sharma, N; Vyas, M; Khurana, N; Maurya, PK; Singh, H; Andreoli de Jesus, TP; Dureja, H; Chellappan, DK; Gupta, G; Wadhwa, R; Collet, T; Hansbro, PM; Dua, K; Satija, S

Interactions with the macrophages: An emerging targeted approach using novel drug delivery systems in respiratory diseases

Mehta, M Deeksha Sharma, N Vyas, M Khurana, N Maurya, PK Singh, H Andreoli de Jesus, TP Dureja, H Chellappan, DK Gupta, G Wadhwa, R Collet, T Hansbro, PM

Dua, K

Satija, S

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Publication Type:: Journal Article
Citation:: Chemico-Biological Interactions, 2019, 304 pp. 10 - 19
Issue Date:: 2019-05-01

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Field	Value	Language
dc.contributor.author	Mehta, M	en_US
dc.contributor.author	Deeksha	en_US
dc.contributor.author	Sharma, N	en_US
dc.contributor.author	Vyas, M	en_US
dc.contributor.author	Khurana, N	en_US
dc.contributor.author	Maurya, PK	en_US
dc.contributor.author	Singh, H	en_US
dc.contributor.author	Andreoli de Jesus, TP	en_US
dc.contributor.author	Dureja, H	en_US
dc.contributor.author	Chellappan, DK	en_US
dc.contributor.author	Gupta, G	en_US
dc.contributor.author	Wadhwa, R	en_US
dc.contributor.author	Collet, T	en_US
dc.contributor.author	Hansbro, PM https://orcid.org/0000-0002-4741-3035	en_US
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159	en_US
dc.contributor.author	Satija, S	en_US
dc.date.available	2019-02-22	en_US
dc.date.issued	2019-05-01	en_US
dc.identifier.citation	Chemico-Biological Interactions, 2019, 304 pp. 10 - 19	en_US
dc.identifier.issn	0009-2797	en_US
dc.identifier.uri	http://hdl.handle.net/10453/131669
dc.description.abstract	© 2019 Macrophages are considered as the most flexible cells of the hematopoietic system that are distributed in the tissues to act against pathogens and foreign particles. Macrophages are essential in maintaining homeostatic tissue processes, repair and immunity. Also, play important role in cytokine secretion and signal transduction of the infection so as to develop acquired immunity. Accounting to their involvement in pathogenesis, macrophages present a therapeutic target for the treatment of inflammatory respiratory diseases. This review focuses on novel drug delivery systems (NDDS) including nanoparticles, liposomes, dendrimers, microspheres etc that can target alveolar macrophage associated with inflammation, intracellular infection and lung cancer. The physiochemical properties and functional moieties of the NDDS attributes to enhanced macrophage targeting and uptake. The NDDS are promising for sustained drug delivery, reduced therapeutic dose, improved patient compliance and reduce drug toxicity. Further, the review also discuss about modified NDDS for specificity to the target and molecular targeting via anti-microbial peptides, kinases, NRF-2 and phosphodiesterase.	en_US
dc.relation	http://purl.org/au-research/grants/nhmrc/GNT1079187
dc.relation.ispartof	Chemico-Biological Interactions	en_US
dc.relation.isbasedon	10.1016/j.cbi.2019.02.021	en_US
dc.subject.classification	Toxicology	en_US
dc.subject.mesh	Macrophages	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Respiratory Tract Diseases	en_US
dc.subject.mesh	Inflammation	en_US
dc.subject.mesh	Drug Delivery Systems	en_US
dc.title	Interactions with the macrophages: An emerging targeted approach using novel drug delivery systems in respiratory diseases	en_US
dc.type	Journal Article
utslib.citation.volume	304	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Students
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	304	en_US

Abstract:

© 2019 Macrophages are considered as the most flexible cells of the hematopoietic system that are distributed in the tissues to act against pathogens and foreign particles. Macrophages are essential in maintaining homeostatic tissue processes, repair and immunity. Also, play important role in cytokine secretion and signal transduction of the infection so as to develop acquired immunity. Accounting to their involvement in pathogenesis, macrophages present a therapeutic target for the treatment of inflammatory respiratory diseases. This review focuses on novel drug delivery systems (NDDS) including nanoparticles, liposomes, dendrimers, microspheres etc that can target alveolar macrophage associated with inflammation, intracellular infection and lung cancer. The physiochemical properties and functional moieties of the NDDS attributes to enhanced macrophage targeting and uptake. The NDDS are promising for sustained drug delivery, reduced therapeutic dose, improved patient compliance and reduce drug toxicity. Further, the review also discuss about modified NDDS for specificity to the target and molecular targeting via anti-microbial peptides, kinases, NRF-2 and phosphodiesterase.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/131669