Identification of biomarkers and genetic approaches toward chronic obstructive pulmonary disease

Wadhwa, R; Aggarwal, T; Malyla, V; Kumar, N; Gupta, G; Chellappan, DK; Dureja, H; Mehta, M; Satija, S; Gulati, M; Maurya, PK; Collet, T; Hansbro, PM; Dua, K

Identification of biomarkers and genetic approaches toward chronic obstructive pulmonary disease

Aggarwal, T Malyla, V Kumar, N Gupta, G Chellappan, DK Dureja, H Mehta, M Satija, S Gulati, M Maurya, PK Collet, T Hansbro, PM

Dua, K

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Publication Type:: Journal Article
Citation:: Journal of Cellular Physiology, 2019, 234 (10), pp. 16703 - 16723
Issue Date:: 2019-10-01

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Field	Value	Language
dc.contributor.author	Wadhwa, R https://orcid.org/0000-0001-8074-1543	en_US
dc.contributor.author	Aggarwal, T	en_US
dc.contributor.author	Malyla, V	en_US
dc.contributor.author	Kumar, N	en_US
dc.contributor.author	Gupta, G	en_US
dc.contributor.author	Chellappan, DK	en_US
dc.contributor.author	Dureja, H	en_US
dc.contributor.author	Mehta, M	en_US
dc.contributor.author	Satija, S	en_US
dc.contributor.author	Gulati, M	en_US
dc.contributor.author	Maurya, PK	en_US
dc.contributor.author	Collet, T	en_US
dc.contributor.author	Hansbro, PM https://orcid.org/0000-0002-4741-3035	en_US
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159	en_US
dc.date.available	2019-02-14	en_US
dc.date.issued	2019-10-01	en_US
dc.identifier.citation	Journal of Cellular Physiology, 2019, 234 (10), pp. 16703 - 16723	en_US
dc.identifier.issn	0021-9541	en_US
dc.identifier.uri	http://hdl.handle.net/10453/131768
dc.description.abstract	© 2019 Wiley Periodicals, Inc. Chronic obstructive pulmonary disease accounts as the leading cause of mortality worldwide prominently affected by genetic and environmental factors. The disease is characterized by persistent coughing, breathlessness airways inflammation followed by a decrease in forced expiratory volume1 and exacerbations, which affect the quality of life. Determination of genetic, epigenetic, and oxidant biomarkers to evaluate the progression of disease has proved complicated and challenging. Approaches including exome sequencing, genome-wide association studies, linkage studies, and inheritance and segregation studies played a crucial role in the identification of genes, their pathways and variation in genes. This review highlights multiple approaches for biomarker and gene identification, which can be used for differential diagnosis along with the genome editing tools to study genes associated with the development of disease and models their function. Further, we have discussed the approaches to rectify the abnormal gene functioning of respiratory tissues and various novel gene editing techniques like Zinc finger nucleases (ZFN), transcription activator-like effector nucleases (TALEN), and clustered regulatory interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9).	en_US
dc.relation	http://purl.org/au-research/grants/nhmrc/GNT1079187
dc.relation.ispartof	Journal of Cellular Physiology	en_US
dc.relation.isbasedon	10.1002/jcp.28482	en_US
dc.subject.classification	Biochemistry & Molecular Biology	en_US
dc.title	Identification of biomarkers and genetic approaches toward chronic obstructive pulmonary disease	en_US
dc.type	Journal Article
utslib.citation.volume	10	en_US
utslib.citation.volume	234	en_US
utslib.for	1116 Medical Physiology	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
pubs.organisational-group	/University of Technology Sydney/Students
utslib.copyright.status	closed_access
pubs.issue	10	en_US
pubs.publication-status	Published	en_US
pubs.volume	234	en_US

Abstract:

© 2019 Wiley Periodicals, Inc. Chronic obstructive pulmonary disease accounts as the leading cause of mortality worldwide prominently affected by genetic and environmental factors. The disease is characterized by persistent coughing, breathlessness airways inflammation followed by a decrease in forced expiratory volume1 and exacerbations, which affect the quality of life. Determination of genetic, epigenetic, and oxidant biomarkers to evaluate the progression of disease has proved complicated and challenging. Approaches including exome sequencing, genome-wide association studies, linkage studies, and inheritance and segregation studies played a crucial role in the identification of genes, their pathways and variation in genes. This review highlights multiple approaches for biomarker and gene identification, which can be used for differential diagnosis along with the genome editing tools to study genes associated with the development of disease and models their function. Further, we have discussed the approaches to rectify the abnormal gene functioning of respiratory tissues and various novel gene editing techniques like Zinc finger nucleases (ZFN), transcription activator-like effector nucleases (TALEN), and clustered regulatory interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9).

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/131768