An overview of circular RNAs

Awasthi, R; Singh, AK; Mishra, G; Maurya, A; Chellappan, DK; Gupta, G; Hansbro, PM; Dua, K

An overview of circular RNAs

Awasthi, R Singh, AK Mishra, G Maurya, A Chellappan, DK Gupta, G Hansbro, PM

Dua, K

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Publication Type:: Chapter
Citation:: Advances in Experimental Medicine and Biology, 2018, 1087 pp. 3 - 14
Issue Date:: 2018-01-01

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Field	Value	Language
dc.contributor.author	Awasthi, R	en_US
dc.contributor.author	Singh, AK	en_US
dc.contributor.author	Mishra, G	en_US
dc.contributor.author	Maurya, A	en_US
dc.contributor.author	Chellappan, DK	en_US
dc.contributor.author	Gupta, G	en_US
dc.contributor.author	Hansbro, PM https://orcid.org/0000-0002-4741-3035	en_US
dc.contributor.author	Dua, K https://orcid.org/0000-0002-7507-1159	en_US
dc.date.issued	2018-01-01	en_US
dc.identifier.citation	Advances in Experimental Medicine and Biology, 2018, 1087 pp. 3 - 14	en_US
dc.identifier.uri	http://hdl.handle.net/10453/132025
dc.description.abstract	© 2018, Springer Nature Singapore Pte Ltd. Circular RNAs (cirRNAs) are long, noncoding endogenous RNA molecules and covalently closed continuous loop without 5′–3′ polarity and polyadenylated tail which are largely concentrated in the nucleus. CirRNA regulates gene expression by modulating microRNAs and functions as potential biomarker. CirRNAs can translate in vivo to link between their expression and disease. They are resistant to RNA exonuclease and can convert to the linear RNA by microRNA which can then act as competitor to endogenous RNA. This chapter summarizes the evolutionary conservation and expression of cirRNAs, their identification, highlighting various computational approaches on cirRNA, and translation with a focus on the breakthroughs and the challenges in this new field.	en_US
dc.relation.ispartof	Advances in Experimental Medicine and Biology	en_US
dc.relation.isbasedon	10.1007/978-981-13-1426-1_1	en_US
dc.subject.classification	General & Internal Medicine	en_US
dc.subject.mesh	MicroRNAs	en_US
dc.subject.mesh	RNA	en_US
dc.subject.mesh	Blotting, Northern	en_US
dc.subject.mesh	In Situ Hybridization, Fluorescence	en_US
dc.subject.mesh	Polymerase Chain Reaction	en_US
dc.subject.mesh	Computational Biology	en_US
dc.subject.mesh	Protein Biosynthesis	en_US
dc.subject.mesh	Gene Expression Regulation	en_US
dc.subject.mesh	RNA Processing, Post-Transcriptional	en_US
dc.subject.mesh	RNA, Long Noncoding	en_US
dc.subject.mesh	RNA, Circular	en_US
dc.title	An overview of circular RNAs	en_US
dc.type	Chapter
utslib.citation.volume	1087	en_US
utslib.for	1115 Pharmacology and Pharmaceutical Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Graduate School of Health
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	1087	en_US

Abstract:

© 2018, Springer Nature Singapore Pte Ltd. Circular RNAs (cirRNAs) are long, noncoding endogenous RNA molecules and covalently closed continuous loop without 5′–3′ polarity and polyadenylated tail which are largely concentrated in the nucleus. CirRNA regulates gene expression by modulating microRNAs and functions as potential biomarker. CirRNAs can translate in vivo to link between their expression and disease. They are resistant to RNA exonuclease and can convert to the linear RNA by microRNA which can then act as competitor to endogenous RNA. This chapter summarizes the evolutionary conservation and expression of cirRNAs, their identification, highlighting various computational approaches on cirRNA, and translation with a focus on the breakthroughs and the challenges in this new field.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/132025