Maternal smoking and foetal brain outcome: mechanisms and possible solutions

Chen, H; Chan, YL; Oliver, B; Pollock, C; Saad, S

Maternal smoking and foetal brain outcome: mechanisms and possible solutions

Chen, H

Chan, YL

Oliver, B

Pollock, C Saad, S

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Publisher:: Academic Press-Elsevier.
Publication Type:: Chapter
Citation:: The Neuroscience of Nicotine: Mechanisms And Treatment., 2019, 1st
Issue Date:: 2019-03-21

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Field	Value	Language
dc.contributor.author	Chen, H https://orcid.org/0000-0001-6883-3752	en_US
dc.contributor.author	Chan, YL https://orcid.org/0000-0002-9605-4200	en_US
dc.contributor.author	Oliver, B https://orcid.org/0000-0002-7122-9262	en_US
dc.contributor.author	Pollock, C	en_US
dc.contributor.author	Saad, S	en_US
dc.contributor.editor	Preedy, V	en_US
dc.date.issued	2019-03-21	en_US
dc.identifier.citation	The Neuroscience of Nicotine: Mechanisms And Treatment., 2019, 1st	en_US
dc.identifier.uri	http://hdl.handle.net/10453/132599
dc.description.abstract	Although it is well known that maternal cigarette smoke exposure (SE) is detrimental to the health of children, more than 20% of women continue to smoke during pregnancy. Children exposed to maternal smoking in utero have changes in their brain structure and size, often accompanied by cognitive defects. This may be due to increased brain oxidative stress and inflammatory response in the neonatal period, leading to neuron damage in adulthood. The mitochondria, a major source of cellular oxidative stress, are particularly vulnerable to the damage caused by the free radicals they produce. Interestingly, the female offspring seem to be protected by such adverse impact of maternal smoking. This chapter will specifically review the changes in brain inflammation and oxidative stress and the mechanism of mitophagy machinery. Potential therapeutic strategies will be suggested to mitigate the impact of maternal smoking.	en_US
dc.publisher	Academic Press-Elsevier.	en_US
dc.relation.ispartof	The Neuroscience of Nicotine: Mechanisms And Treatment.	en_US
dc.title	Maternal smoking and foetal brain outcome: mechanisms and possible solutions	en_US
dc.type	Chapter
utslib.location	New York	en_US
utslib.citation.edition	1st	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	closed_access
pubs.consider-herdc	false	en_US
pubs.edition	1st	en_US
pubs.place-of-publication	New York	en_US
pubs.publication-status	Published	en_US

Abstract:

Although it is well known that maternal cigarette smoke exposure (SE) is detrimental to the health of children, more than 20% of women continue to smoke during pregnancy. Children exposed to maternal smoking in utero have changes in their brain structure and size, often accompanied by cognitive defects. This may be due to increased brain oxidative stress and inflammatory response in the neonatal period, leading to neuron damage in adulthood. The mitochondria, a major source of cellular oxidative stress, are particularly vulnerable to the damage caused by the free radicals they produce. Interestingly, the female offspring seem to be protected by such adverse impact of maternal smoking. This chapter will specifically review the changes in brain inflammation and oxidative stress and the mechanism of mitophagy machinery. Potential therapeutic strategies will be suggested to mitigate the impact of maternal smoking.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/132599