Microfluidics for fast and frugal diagnosis of malaria, sepsis, and HIV/AIDS

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Frugal Innovation in Bioengineering for the Detection of Infectious Diseases, 2018, pp. 57 - 75
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© Springer International Publishing AG 2018. Rapid diagnosis of infectious diseases is necessary for timely treatment and to control spread of diseases. Conventional laboratory approaches are often labor-intensive and associated with time delays that are unacceptable in medical practice. Recent advances in micro-/nanotechnologies have facilitated the development of low-cost microfluidic devices with high sensitivity and throughput that can help reduce healthcare costs and pave the way toward personalized therapy. This chapter covers recent advances in point-of-care (POC) technologies with an emphasis on demonstrated and commercially available systems for diagnosis and treatment of malaria, sepsis, and human immunodeficiency virus (HIV) infection/acquired immune deficiency syndrome (AIDS). The current challenges to practical implementation of these technologies are discussed together with some future perspectives.
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