Immunoproteomic approach to elucidating the pathogenesis of cryptococcosis caused by cryptococcus gattii

Jobbins, SE; Hill, CJ; D'Souza-Basseal, JM; Padula, MP; Herbert, BR; Krockenberger, MB

Immunoproteomic approach to elucidating the pathogenesis of cryptococcosis caused by cryptococcus gattii

Jobbins, SE Hill, CJ D'Souza-Basseal, JM Padula, MP

Herbert, BR

Krockenberger, MB

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Publication Type:: Journal Article
Citation:: Journal of Proteome Research, 2010, 9 (8), pp. 3832 - 3841
Issue Date:: 2010-08-06

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Field	Value	Language
dc.contributor.author	Jobbins, SE	en_US
dc.contributor.author	Hill, CJ	en_US
dc.contributor.author	D'Souza-Basseal, JM	en_US
dc.contributor.author	Padula, MP https://orcid.org/0000-0002-8283-0643	en_US
dc.contributor.author	Herbert, BR https://orcid.org/0000-0003-4697-8197	en_US
dc.contributor.author	Krockenberger, MB	en_US
dc.date.issued	2010-08-06	en_US
dc.identifier.citation	Journal of Proteome Research, 2010, 9 (8), pp. 3832 - 3841	en_US
dc.identifier.issn	1535-3893	en_US
dc.identifier.uri	http://hdl.handle.net/10453/13319
dc.description.abstract	Cryptococcosis caused by Cryptococcus gattii is a devastating disease of immunocompetent hosts with an incompletely understood pathogenesis. Utilizing an immunoproteomic approach in a naturally occurring koala model of disease, a number of key proteins and pathways are identified in the early and late pathogenesis of cryptococcosis for the first time. In particular, the thioredoxin system appears important in the pathogenesis of cryptococcosis caused by C. gattii VGII. © 2010 American Chemical Society.	en_US
dc.relation.ispartof	Journal of Proteome Research	en_US
dc.relation.isbasedon	10.1021/pr100028t	en_US
dc.subject.classification	Biochemistry & Molecular Biology	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Phascolarctidae	en_US
dc.subject.mesh	Cryptococcosis	en_US
dc.subject.mesh	Antibodies, Fungal	en_US
dc.subject.mesh	Antigens, Fungal	en_US
dc.subject.mesh	Immunoblotting	en_US
dc.subject.mesh	Electrophoresis, Gel, Two-Dimensional	en_US
dc.subject.mesh	Proteomics	en_US
dc.subject.mesh	Australia	en_US
dc.subject.mesh	Cryptococcus gattii	en_US
dc.title	Immunoproteomic approach to elucidating the pathogenesis of cryptococcosis caused by cryptococcus gattii	en_US
dc.type	Journal Article
utslib.citation.volume	8	en_US
utslib.citation.volume	9	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	03 Chemical Sciences	en_US
utslib.for	06 Biological Sciences	en_US
dc.location.activity	ISI:000280583700007	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.issue	8	en_US
pubs.publication-status	Published	en_US
pubs.volume	9	en_US

Abstract:

Cryptococcosis caused by Cryptococcus gattii is a devastating disease of immunocompetent hosts with an incompletely understood pathogenesis. Utilizing an immunoproteomic approach in a naturally occurring koala model of disease, a number of key proteins and pathways are identified in the early and late pathogenesis of cryptococcosis for the first time. In particular, the thioredoxin system appears important in the pathogenesis of cryptococcosis caused by C. gattii VGII. © 2010 American Chemical Society.

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http://hdl.handle.net/10453/13319