Use Of Live Attenuated Bacteria To Stimulate Immunity

Editions Scientifiques Elsevier
Publication Type:
Journal Article
Research in Microbiology, 1990, 141 (7-8), pp. 769 - 773
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Many bacteria, including Salmonella, Listeria, and Yersinia species, can cause severe systemic infections of mammals. These invasive bacteria appear to have developed sophisticated mechanisms for entry into, and survival within, eukaryotic cells. Genetic manipulation of these organisms has led to the isolation of mutants which have an impaired ability to survive in vivo, and some of these mutants have been used as live oral vaccines to immunize against virulent infection. In this review, we shall outline some of the work carried out in our laboratory on the analysis of these bacteria, including the construction of auxotrophic mutants and their use in carrying foreign antigens to the immune system. In addition, the use of secreted proteins as immunogens and as carriers of epitopes will be discussed.
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