Non-archetypal Type II-like and atypical strains of Toxoplasma gondii infecting marsupials of Australia

Parameswaran, N; Thompson, RCA; Sundar, N; Pan, S; Johnson, M; Smith, NC; Grigg, ME

Non-archetypal Type II-like and atypical strains of Toxoplasma gondii infecting marsupials of Australia

Parameswaran, N Thompson, RCA Sundar, N Pan, S Johnson, M Smith, NC

Grigg, ME

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Publication Type:: Journal Article
Citation:: International Journal for Parasitology, 2010, 40 (6), pp. 635 - 640
Issue Date:: 2010-05-01

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Field	Value	Language
dc.contributor.author	Parameswaran, N	en_US
dc.contributor.author	Thompson, RCA	en_US
dc.contributor.author	Sundar, N	en_US
dc.contributor.author	Pan, S	en_US
dc.contributor.author	Johnson, M	en_US
dc.contributor.author	Smith, NC https://orcid.org/0000-0002-7467-1451	en_US
dc.contributor.author	Grigg, ME	en_US
dc.date.available	2010-02-15	en_US
dc.date.issued	2010-05-01	en_US
dc.identifier.citation	International Journal for Parasitology, 2010, 40 (6), pp. 635 - 640	en_US
dc.identifier.issn	0020-7519	en_US
dc.identifier.uri	http://hdl.handle.net/10453/13336
dc.description.abstract	Australia is geographically isolated and possesses a remarkable diversity of wildlife species. Marsupials are highly susceptible to infection with the cosmopolitan parasite Toxoplasma gondii. Of 46 marsupials screened for T. gondii by multilocus PCR-DNA sequencing at polymorphic genes (B1, SAG3, GRA6, GRA7), 12 were PCR-positive; the majority (67%; 9/12) were infected by non-archetypal Type II-like or atypical strains. Six novel alleles were detected at B1, indicating greater diversity of genotypes than previously envisaged. Two isolates lethal to marsupials, were avirulent to mice. The data support the conclusion that Australia's isolation may have favoured the persistence of non-archetypal ancestral genotypes. © 2010.	en_US
dc.relation.ispartof	International Journal for Parasitology	en_US
dc.relation.isbasedon	10.1016/j.ijpara.2010.02.008	en_US
dc.subject.classification	Mycology & Parasitology	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Marsupialia	en_US
dc.subject.mesh	Mice	en_US
dc.subject.mesh	Toxoplasma	en_US
dc.subject.mesh	Toxoplasmosis, Animal	en_US
dc.subject.mesh	DNA, Protozoan	en_US
dc.subject.mesh	Cluster Analysis	en_US
dc.subject.mesh	Survival Analysis	en_US
dc.subject.mesh	Polymerase Chain Reaction	en_US
dc.subject.mesh	Sequence Analysis, DNA	en_US
dc.subject.mesh	Virulence	en_US
dc.subject.mesh	Genotype	en_US
dc.subject.mesh	Polymorphism, Genetic	en_US
dc.subject.mesh	Australia	en_US
dc.title	Non-archetypal Type II-like and atypical strains of Toxoplasma gondii infecting marsupials of Australia	en_US
dc.type	Journal Article
utslib.citation.volume	6	en_US
utslib.citation.volume	40	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	0608 Zoology	en_US
utslib.for	0707 Veterinary Sciences	en_US
dc.location.activity	ISI:000277733200001	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/DVC (Teaching and Learning)
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.issue	6	en_US
pubs.publication-status	Published	en_US
pubs.volume	40	en_US

Abstract:

Australia is geographically isolated and possesses a remarkable diversity of wildlife species. Marsupials are highly susceptible to infection with the cosmopolitan parasite Toxoplasma gondii. Of 46 marsupials screened for T. gondii by multilocus PCR-DNA sequencing at polymorphic genes (B1, SAG3, GRA6, GRA7), 12 were PCR-positive; the majority (67%; 9/12) were infected by non-archetypal Type II-like or atypical strains. Six novel alleles were detected at B1, indicating greater diversity of genotypes than previously envisaged. Two isolates lethal to marsupials, were avirulent to mice. The data support the conclusion that Australia's isolation may have favoured the persistence of non-archetypal ancestral genotypes. © 2010.

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http://hdl.handle.net/10453/13336