Peroxiredoxin: A central player in immune modulation

Robinson, MW; Hutchinson, AT; Dalton, JP; Donnelly, S

Peroxiredoxin: A central player in immune modulation

Robinson, MW

Hutchinson, AT Dalton, JP Donnelly, S

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Publication Type:: Journal Article
Citation:: Parasite Immunology, 2010, 32 (5), pp. 305 - 313
Issue Date:: 2010-05-01

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Field	Value	Language
dc.contributor.author	Robinson, MW https://orcid.org/0000-0001-7191-0034	en_US
dc.contributor.author	Hutchinson, AT	en_US
dc.contributor.author	Dalton, JP	en_US
dc.contributor.author	Donnelly, S https://orcid.org/0000-0003-2005-3698	en_US
dc.date.issued	2010-05-01	en_US
dc.identifier.citation	Parasite Immunology, 2010, 32 (5), pp. 305 - 313	en_US
dc.identifier.issn	0141-9838	en_US
dc.identifier.uri	http://hdl.handle.net/10453/13376
dc.description.abstract	Peroxiredoxins (Prx) are a family of anti-oxidants that protect cells from metabolically produced reactive oxygen species (ROS). The presence of these enzymes in the secretomes of many parasitic helminths suggests they provide protection against ROS released by host immune effector cells. However, we recently reported that helminth-secreted Prx also contribute to the development of Th2-responses via a mechanism involving the induction of alternatively activated macrophages. In this review, we discuss the role helminth Prx may play in modulating the immune responses of their hosts. © 2010 Blackwell Publishing Ltd.	en_US
dc.relation.ispartof	Parasite Immunology	en_US
dc.relation.isbasedon	10.1111/j.1365-3024.2010.01201.x	en_US
dc.subject.classification	Mycology & Parasitology	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Helminth Proteins	en_US
dc.subject.mesh	Peroxiredoxins	en_US
dc.title	Peroxiredoxin: A central player in immune modulation	en_US
dc.type	Journal Article
utslib.citation.volume	5	en_US
utslib.citation.volume	32	en_US
utslib.for	0707 Veterinary Sciences	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	1108 Medical Microbiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.issue	5	en_US
pubs.publication-status	Published	en_US
pubs.volume	32	en_US

Abstract:

Peroxiredoxins (Prx) are a family of anti-oxidants that protect cells from metabolically produced reactive oxygen species (ROS). The presence of these enzymes in the secretomes of many parasitic helminths suggests they provide protection against ROS released by host immune effector cells. However, we recently reported that helminth-secreted Prx also contribute to the development of Th2-responses via a mechanism involving the induction of alternatively activated macrophages. In this review, we discuss the role helminth Prx may play in modulating the immune responses of their hosts. © 2010 Blackwell Publishing Ltd.

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http://hdl.handle.net/10453/13376