The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola

Cwiklinski, K; Donnelly, S; Drysdale, O; Jewhurst, H; Smith, D; De Marco Verissimo, C; Pritsch, IC; O'Neill, S; Dalton, JP; Robinson, MW

The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola

Cwiklinski, K Donnelly, S

Drysdale, O Jewhurst, H Smith, D De Marco Verissimo, C Pritsch, IC O'Neill, S Dalton, JP Robinson, MW

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Publication Type:: Chapter
Citation:: Advances in Parasitology, 2019, 104 pp. 113 - 164
Issue Date:: 2019-01-01

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Field	Value	Language
dc.contributor.author	Cwiklinski, K	en_US
dc.contributor.author	Donnelly, S https://orcid.org/0000-0003-2005-3698	en_US
dc.contributor.author	Drysdale, O	en_US
dc.contributor.author	Jewhurst, H	en_US
dc.contributor.author	Smith, D	en_US
dc.contributor.author	De Marco Verissimo, C	en_US
dc.contributor.author	Pritsch, IC	en_US
dc.contributor.author	O'Neill, S	en_US
dc.contributor.author	Dalton, JP	en_US
dc.contributor.author	Robinson, MW	en_US
dc.date.issued	2019-01-01	en_US
dc.identifier.citation	Advances in Parasitology, 2019, 104 pp. 113 - 164	en_US
dc.identifier.isbn	9780128177167	en_US
dc.identifier.uri	http://hdl.handle.net/10453/133849
dc.description.abstract	© 2019 Elsevier Ltd Fasciolosis caused by trematode parasites of the genus Fasciola is a global disease of livestock, particularly cattle, sheep, water buffalo and goats. It is also a major human zoonosis with reports suggesting that 2.4–17 million people are infected worldwide, and 91.1 million people currently living at risk of infection. A unique feature of these worms is their reliance on a family of developmentally-regulated papain-like cysteine peptidases, termed cathepsins. These proteolytic enzymes play central roles in virulence, infection, tissue migration and modulation of host innate and adaptive immune responses. The availability of a Fasciola hepatica genome, and the exploitation of transcriptomic and proteomic technologies to probe parasite growth and development, has enlightened our understanding of the cathepsin-like cysteine peptidases. Here, we clarify the structure of the cathepsin-like cysteine peptidase families and, in this context, review the phylogenetics, structure, biochemistry and function of these enzymes in the host-parasite relationship.	en_US
dc.relation.ispartof	Advances in Parasitology	en_US
dc.relation.isbasedon	10.1016/bs.apar.2019.01.001	en_US
dc.subject.classification	Mycology & Parasitology	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Fasciola	en_US
dc.subject.mesh	Peptide Hydrolases	en_US
dc.subject.mesh	Genome, Helminth	en_US
dc.subject.mesh	Host-Parasite Interactions	en_US
dc.title	The cathepsin-like cysteine peptidases of trematodes of the genus Fasciola	en_US
dc.type	Chapter
utslib.citation.volume	104	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	0707 Veterinary Sciences	en_US
utslib.for	1108 Medical Microbiology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	104	en_US

Abstract:

© 2019 Elsevier Ltd Fasciolosis caused by trematode parasites of the genus Fasciola is a global disease of livestock, particularly cattle, sheep, water buffalo and goats. It is also a major human zoonosis with reports suggesting that 2.4–17 million people are infected worldwide, and 91.1 million people currently living at risk of infection. A unique feature of these worms is their reliance on a family of developmentally-regulated papain-like cysteine peptidases, termed cathepsins. These proteolytic enzymes play central roles in virulence, infection, tissue migration and modulation of host innate and adaptive immune responses. The availability of a Fasciola hepatica genome, and the exploitation of transcriptomic and proteomic technologies to probe parasite growth and development, has enlightened our understanding of the cathepsin-like cysteine peptidases. Here, we clarify the structure of the cathepsin-like cysteine peptidase families and, in this context, review the phylogenetics, structure, biochemistry and function of these enzymes in the host-parasite relationship.

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http://hdl.handle.net/10453/133849