LA-ICP-MS/MS improves limits of detection in elemental bioimaging of gadolinium deposition originating from MRI contrast agents in skin and brain tissues

Clases, D; Fingerhut, S; Jeibmann, A; Sperling, M; Doble, P; Karst, U

LA-ICP-MS/MS improves limits of detection in elemental bioimaging of gadolinium deposition originating from MRI contrast agents in skin and brain tissues

Clases, D

Fingerhut, S Jeibmann, A Sperling, M Doble, P

Karst, U

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Publication Type:: Journal Article
Citation:: Journal of Trace Elements in Medicine and Biology, 2019, 51 pp. 212 - 218
Issue Date:: 2019-01-01

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Field	Value	Language
dc.contributor.author	Clases, D https://orcid.org/0000-0003-3880-9385	en_US
dc.contributor.author	Fingerhut, S	en_US
dc.contributor.author	Jeibmann, A	en_US
dc.contributor.author	Sperling, M	en_US
dc.contributor.author	Doble, P https://orcid.org/0000-0002-8472-1301	en_US
dc.contributor.author	Karst, U	en_US
dc.date.available	2018-10-29	en_US
dc.date.issued	2019-01-01	en_US
dc.identifier.citation	Journal of Trace Elements in Medicine and Biology, 2019, 51 pp. 212 - 218	en_US
dc.identifier.issn	0946-672X	en_US
dc.identifier.uri	http://hdl.handle.net/10453/133950
dc.description.abstract	© 2018 Elsevier GmbH A novel analytical method to detect the retention of gadolinium from contrast agents for magnetic resonance imaging (MRI) in tissue samples of patients is presented. It is based on laser ablation - inductively coupled plasma - triple quadrupole - mass spectrometry (LA-ICP-MS/MS). Both Gd and P were monitored with a mass shift of +16, corresponding to mono-oxygenated species, as well as Zn, Ca, and Fe on-mass. This method resulted in a significantly reduced background and improved limits of detection not only for phosphorus, but also for gadolinium. These improvements were essential to perform elemental bioimaging with improved resolution of 5 μm x 5 μm, allowing the detection of small Gd deposits in fibrotic skin and brain tumour tissue with diameters of approximately 50 μm. Detailed analyses of these regions revealed that most Gd was accompanied with P and Ca, indicating co-precipitation.	en_US
dc.relation	http://purl.org/au-research/grants/arc/DP170100036
dc.relation.ispartof	Journal of Trace Elements in Medicine and Biology	en_US
dc.relation.isbasedon	10.1016/j.jtemb.2018.10.021	en_US
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	Toxicology	en_US
dc.subject.mesh	Brain	en_US
dc.subject.mesh	Skin	en_US
dc.subject.mesh	Humans	en_US
dc.subject.mesh	Gadolinium	en_US
dc.subject.mesh	Contrast Media	en_US
dc.subject.mesh	Magnetic Resonance Imaging	en_US
dc.subject.mesh	Adult	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Tandem Mass Spectrometry	en_US
dc.subject.mesh	Laser Therapy	en_US
dc.subject.mesh	Nephrogenic Fibrosing Dermopathy	en_US
dc.subject.mesh	Limit of Detection	en_US
dc.title	LA-ICP-MS/MS improves limits of detection in elemental bioimaging of gadolinium deposition originating from MRI contrast agents in skin and brain tissues	en_US
dc.type	Journal Article
utslib.citation.volume	51	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
utslib.copyright.status	open_access	*
pubs.publication-status	Published	en_US
pubs.volume	51	en_US

Abstract:

© 2018 Elsevier GmbH A novel analytical method to detect the retention of gadolinium from contrast agents for magnetic resonance imaging (MRI) in tissue samples of patients is presented. It is based on laser ablation - inductively coupled plasma - triple quadrupole - mass spectrometry (LA-ICP-MS/MS). Both Gd and P were monitored with a mass shift of +16, corresponding to mono-oxygenated species, as well as Zn, Ca, and Fe on-mass. This method resulted in a significantly reduced background and improved limits of detection not only for phosphorus, but also for gadolinium. These improvements were essential to perform elemental bioimaging with improved resolution of 5 μm x 5 μm, allowing the detection of small Gd deposits in fibrotic skin and brain tumour tissue with diameters of approximately 50 μm. Detailed analyses of these regions revealed that most Gd was accompanied with P and Ca, indicating co-precipitation.

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http://hdl.handle.net/10453/133950