Oxygen-Vacancy Engineering of Cerium-Oxide Nanoparticles for Antioxidant Activity

Gunawan, C; Lord, MS; Lovell, E; Wong, RJ; Jung, MS; Oscar, D; Mann, R; Amal, R

Oxygen-Vacancy Engineering of Cerium-Oxide Nanoparticles for Antioxidant Activity

Gunawan, C

Lord, MS

Lovell, E

Wong, RJ

Jung, MS Oscar, D Mann, R

Amal, R

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Publication Type:: Journal Article
Citation:: ACS Omega, 2019, 4 (5), pp. 9473 - 9479
Issue Date:: 2019-01-01

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Field	Value	Language
dc.contributor.author	Gunawan, C https://orcid.org/0000-0002-2957-1347	en_US
dc.contributor.author	Lord, MS https://orcid.org/0000-0002-0506-9811	en_US
dc.contributor.author	Lovell, E https://orcid.org/0000-0002-9027-0316	en_US
dc.contributor.author	Wong, RJ https://orcid.org/0000-0002-3260-877X	en_US
dc.contributor.author	Jung, MS	en_US
dc.contributor.author	Oscar, D	en_US
dc.contributor.author	Mann, R https://orcid.org/0000-0003-4772-0139	en_US
dc.contributor.author	Amal, R https://orcid.org/0000-0001-9561-4918	en_US
dc.date.available	2019-05-17	en_US
dc.date.issued	2019-01-01	en_US
dc.identifier.citation	ACS Omega, 2019, 4 (5), pp. 9473 - 9479	en_US
dc.identifier.uri	http://hdl.handle.net/10453/134030
dc.description.abstract	© 2019 American Chemical Society. To address an important challenge in the engineering of antioxidant nanoparticles, the present work devised a surface-to-bulk migration of oxygen vacancies in the oxygen radical-scavenging cerium-oxide nanoparticles. The study highlights the significance of surface oxygen vacancies in the intended cellular internalization and, subsequently, the radical scavenging activity of the nanoparticles inside the cells. The findings advise future development of therapeutic antioxidant nanomaterials to also include engineering of the particles for enhanced surface defects not only for the accessibility of their oxygen vacancies but also, equally important, rendering them bioavailable for cellular uptake.	en_US
dc.relation	http://purl.org/au-research/grants/arc/DP180100474
dc.relation.ispartof	ACS Omega	en_US
dc.relation.isbasedon	10.1021/acsomega.9b00521	en_US
dc.title	Oxygen-Vacancy Engineering of Cerium-Oxide Nanoparticles for Antioxidant Activity	en_US
dc.type	Journal Article
utslib.citation.volume	5	en_US
utslib.citation.volume	4	en_US
utslib.for	1007 Nanotechnology	en_US
utslib.for	0904 Chemical Engineering	en_US
utslib.for	0912 Materials Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - ithree - Institute of Infection, Immunity and Innovation
utslib.copyright.status	open_access
pubs.issue	5	en_US
pubs.publication-status	Published	en_US
pubs.volume	4	en_US

Abstract:

© 2019 American Chemical Society. To address an important challenge in the engineering of antioxidant nanoparticles, the present work devised a surface-to-bulk migration of oxygen vacancies in the oxygen radical-scavenging cerium-oxide nanoparticles. The study highlights the significance of surface oxygen vacancies in the intended cellular internalization and, subsequently, the radical scavenging activity of the nanoparticles inside the cells. The findings advise future development of therapeutic antioxidant nanomaterials to also include engineering of the particles for enhanced surface defects not only for the accessibility of their oxygen vacancies but also, equally important, rendering them bioavailable for cellular uptake.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/134030