Impact of maternal e-cigarette vapor exposure on renal health in the offspring

Li, G; Chan, YL; Nguyen, LT; Mak, C; Zaky, A; Anwer, AG; Shi, Y; Nguyen, T; Pollock, CA; Oliver, BG; Saad, S; Chen, H

Impact of maternal e-cigarette vapor exposure on renal health in the offspring

Li, G Chan, YL

Nguyen, LT

Mak, C Zaky, A Anwer, AG Shi, Y Nguyen, T

Pollock, CA Oliver, BG

Saad, S

Chen, H

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Publication Type:: Journal Article
Citation:: Annals of the New York Academy of Sciences, 2019, 1452 (1), pp. 65 - 77
Issue Date:: 2019-09-01

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Field	Value	Language
dc.contributor.author	Li, G	en_US
dc.contributor.author	Chan, YL https://orcid.org/0000-0002-9605-4200	en_US
dc.contributor.author	Nguyen, LT https://orcid.org/0000-0002-0630-4959	en_US
dc.contributor.author	Mak, C	en_US
dc.contributor.author	Zaky, A	en_US
dc.contributor.author	Anwer, AG	en_US
dc.contributor.author	Shi, Y	en_US
dc.contributor.author	Nguyen, T https://orcid.org/0000-0001-6371-4105	en_US
dc.contributor.author	Pollock, CA	en_US
dc.contributor.author	Oliver, BG https://orcid.org/0000-0002-7122-9262	en_US
dc.contributor.author	Saad, S https://orcid.org/0000-0001-8067-8046	en_US
dc.contributor.author	Chen, H https://orcid.org/0000-0001-6883-3752	en_US
dc.date.available	2020-07-18T19:05:28Z
dc.date.issued	2019-09-01	en_US
dc.identifier.citation	Annals of the New York Academy of Sciences, 2019, 1452 (1), pp. 65 - 77	en_US
dc.identifier.issn	0077-8923	en_US
dc.identifier.uri	http://hdl.handle.net/10453/134683
dc.description.abstract	© 2019 New York Academy of Sciences. Maternal smoking during pregnancy is a significant risk factor of renal pathology in the offspring. E-cigarettes are perceived to be a safe option and are increasingly used by pregnant women either continuously during pregnancy or as a replacement for tobacco cigarettes. This study aimed to determine the effects of replacing tobacco cigarettes with e-cigarettes during pregnancy, and continuous e-cigarette use during pregnancy on the offspring's kidneys. Female Balb/c mice were exposed to either air (sham) or tobacco cigarette smoke (SE) for 6 weeks prior to mating, during gestation and lactation. A subset of the “SE group” received e-cigarette vapor (containing nicotine) after mating until pups weaned. Additional female mice were continuously exposed to e-vapor (either with or without nicotine) for 6 weeks prior to mating until pups weaned. Kidneys and urine from the male offspring were assessed at postnatal day 1, day 20 (weaning), and 13 weeks of age (adulthood). E-cigarette replacement was less detrimental to renal development and albuminuria than continuous SE during pregnancy. However, continuous e-vapor exposure during pregnancy increased markers of oxidative stress, inflammation, and fibrosis in the adult offspring, independent of nicotine. E-cigarette use during pregnancy confers future risk to the offspring's kidneys.	en_US
dc.relation	http://purl.org/au-research/grants/nhmrc/APP1026880
dc.relation	http://purl.org/au-research/grants/nhmrc/APP1104704
dc.relation	http://purl.org/au-research/grants/nhmrc/APP1110368
dc.relation.ispartof	Annals of the New York Academy of Sciences	en_US
dc.relation.isbasedon	10.1111/nyas.14174	en_US
dc.rights	info:eu-repo/semantics/openAccess
dc.subject.classification	General Science & Technology	en_US
dc.subject.mesh	Kidney	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Mice, Inbred BALB C	en_US
dc.subject.mesh	Mice	en_US
dc.subject.mesh	Prenatal Exposure Delayed Effects	en_US
dc.subject.mesh	Fibrosis	en_US
dc.subject.mesh	Environmental Exposure	en_US
dc.subject.mesh	Maternal Exposure	en_US
dc.subject.mesh	Oxidative Stress	en_US
dc.subject.mesh	Pregnancy	en_US
dc.subject.mesh	Female	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Biomarkers	en_US
dc.subject.mesh	E-Cigarette Vapor	en_US
dc.title	Impact of maternal e-cigarette vapor exposure on renal health in the offspring	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	1452	en_US
utslib.for	1101 Medical Biochemistry and Metabolomics	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
pubs.organisational-group	/University of Technology Sydney/Provost
pubs.organisational-group	/University of Technology Sydney/Provost/Jumbunna
pubs.organisational-group	/University of Technology Sydney/Strength - CHT - Health Technologies
utslib.copyright.status	open_access	*
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	1452	en_US

Abstract:

© 2019 New York Academy of Sciences. Maternal smoking during pregnancy is a significant risk factor of renal pathology in the offspring. E-cigarettes are perceived to be a safe option and are increasingly used by pregnant women either continuously during pregnancy or as a replacement for tobacco cigarettes. This study aimed to determine the effects of replacing tobacco cigarettes with e-cigarettes during pregnancy, and continuous e-cigarette use during pregnancy on the offspring's kidneys. Female Balb/c mice were exposed to either air (sham) or tobacco cigarette smoke (SE) for 6 weeks prior to mating, during gestation and lactation. A subset of the “SE group” received e-cigarette vapor (containing nicotine) after mating until pups weaned. Additional female mice were continuously exposed to e-vapor (either with or without nicotine) for 6 weeks prior to mating until pups weaned. Kidneys and urine from the male offspring were assessed at postnatal day 1, day 20 (weaning), and 13 weeks of age (adulthood). E-cigarette replacement was less detrimental to renal development and albuminuria than continuous SE during pregnancy. However, continuous e-vapor exposure during pregnancy increased markers of oxidative stress, inflammation, and fibrosis in the adult offspring, independent of nicotine. E-cigarette use during pregnancy confers future risk to the offspring's kidneys.

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http://hdl.handle.net/10453/134683