Dietary zinc and the control of Streptococcus pneumoniae infection

Eijkelkamp, BA; Morey, JR; Neville, SL; Tan, A; Pederick, VG; Cole, N; Singh, PP; Ong, CLY; De Vega, RG; Clases, D; Cunningham, BA; Hughes, CE; Comerford, I; Brazel, EB; Whittall, JJ; Plumptre, CD; McColl, SR; Paton, JC; McEwan, AG; Doble, PA; McDevitt, CA

Dietary zinc and the control of Streptococcus pneumoniae infection

Eijkelkamp, BA

Morey, JR Neville, SL

Tan, A

Pederick, VG

Cole, N

Singh, PP Ong, CLY De Vega, RG Clases, D

Cunningham, BA

Hughes, CE

Comerford, I Brazel, EB

Whittall, JJ Plumptre, CD McColl, SR Paton, JC McEwan, AG

Doble, PA

McDevitt, CA

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Publication Type:: Journal Article
Citation:: PLoS Pathogens, 2019, 15 (8)
Issue Date:: 2019-01-01

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Field	Value	Language
dc.contributor.author	Eijkelkamp, BA https://orcid.org/0000-0003-0179-8977	en_US
dc.contributor.author	Morey, JR	en_US
dc.contributor.author	Neville, SL https://orcid.org/0000-0002-7298-9335	en_US
dc.contributor.author	Tan, A https://orcid.org/0000-0002-7257-1051	en_US
dc.contributor.author	Pederick, VG https://orcid.org/0000-0001-9830-1060	en_US
dc.contributor.author	Cole, N https://orcid.org/0000-0002-9866-4694	en_US
dc.contributor.author	Singh, PP	en_US
dc.contributor.author	Ong, CLY	en_US
dc.contributor.author	De Vega, RG	en_US
dc.contributor.author	Clases, D https://orcid.org/0000-0003-3880-9385	en_US
dc.contributor.author	Cunningham, BA https://orcid.org/0000-0003-4654-1972	en_US
dc.contributor.author	Hughes, CE https://orcid.org/0000-0002-2152-0238	en_US
dc.contributor.author	Comerford, I	en_US
dc.contributor.author	Brazel, EB https://orcid.org/0000-0001-6632-687X	en_US
dc.contributor.author	Whittall, JJ	en_US
dc.contributor.author	Plumptre, CD	en_US
dc.contributor.author	McColl, SR	en_US
dc.contributor.author	Paton, JC	en_US
dc.contributor.author	McEwan, AG https://orcid.org/0000-0002-2419-1003	en_US
dc.contributor.author	Doble, PA https://orcid.org/0000-0002-8472-1301	en_US
dc.contributor.author	McDevitt, CA https://orcid.org/0000-0003-1596-4841	en_US
dc.date.available	2019-07-03	en_US
dc.date.issued	2019-01-01	en_US
dc.identifier.citation	PLoS Pathogens, 2019, 15 (8)	en_US
dc.identifier.issn	1553-7366	en_US
dc.identifier.uri	http://hdl.handle.net/10453/135794
dc.description.abstract	© 2019 Eijkelkamp et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Human zinc deficiency increases susceptibility to bacterial infection. Although zinc supplementation therapies can reduce the impact of disease, the molecular basis for protection remains unclear. Streptococcus pneumoniae is a major cause of bacterial pneumonia, which is prevalent in regions of zinc deficiency. We report that dietary zinc levels dictate the outcome of S. pneumoniae infection in a murine model. Dietary zinc restriction impacts murine tissue zinc levels with distribution post-infection altered, and S. pneumoniae virulence and infection enhanced. Although the activation and infiltration of murine phagocytic cells was not affected by zinc restriction, their efficacy of bacterial control was compromised. S. pneumoniae was shown to be highly sensitive to zinc intoxication, with this process impaired in zinc restricted mice and isolated phagocytic cells. Collectively, these data show how dietary zinc deficiency increases sensitivity to S. pneumoniae infection while revealing a role for zinc as a component of host antimicrobial defences.	en_US
dc.relation	http://purl.org/au-research/grants/arc/DP170100036
dc.relation	http://purl.org/au-research/grants/arc/DP190102361
dc.relation.ispartof	PLoS Pathogens	en_US
dc.relation.isbasedon	10.1371/journal.ppat.1007957	en_US
dc.subject.classification	Virology	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Mice	en_US
dc.subject.mesh	Streptococcus pneumoniae	en_US
dc.subject.mesh	Pneumococcal Infections	en_US
dc.subject.mesh	Lung Diseases	en_US
dc.subject.mesh	Disease Models, Animal	en_US
dc.subject.mesh	Zinc	en_US
dc.subject.mesh	Virulence	en_US
dc.subject.mesh	Dietary Supplements	en_US
dc.subject.mesh	Female	en_US
dc.title	Dietary zinc and the control of Streptococcus pneumoniae infection	en_US
dc.type	Journal Article
utslib.citation.volume	8	en_US
utslib.citation.volume	15	en_US
utslib.for	1108 Medical Microbiology	en_US
utslib.for	0605 Microbiology	en_US
utslib.for	1107 Immunology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
utslib.copyright.status	open_access
pubs.issue	8	en_US
pubs.publication-status	Published	en_US
pubs.volume	15	en_US

Abstract:

© 2019 Eijkelkamp et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Human zinc deficiency increases susceptibility to bacterial infection. Although zinc supplementation therapies can reduce the impact of disease, the molecular basis for protection remains unclear. Streptococcus pneumoniae is a major cause of bacterial pneumonia, which is prevalent in regions of zinc deficiency. We report that dietary zinc levels dictate the outcome of S. pneumoniae infection in a murine model. Dietary zinc restriction impacts murine tissue zinc levels with distribution post-infection altered, and S. pneumoniae virulence and infection enhanced. Although the activation and infiltration of murine phagocytic cells was not affected by zinc restriction, their efficacy of bacterial control was compromised. S. pneumoniae was shown to be highly sensitive to zinc intoxication, with this process impaired in zinc restricted mice and isolated phagocytic cells. Collectively, these data show how dietary zinc deficiency increases sensitivity to S. pneumoniae infection while revealing a role for zinc as a component of host antimicrobial defences.

Please use this identifier to cite or link to this item:

http://hdl.handle.net/10453/135794