Micro solid-phase extraction for the analysis of per- and polyfluoroalkyl substances in environmental waters

Lockwood, TE; Talebi, M; Minett, A; Mills, S; Doble, PA; Bishop, DP

Micro solid-phase extraction for the analysis of per- and polyfluoroalkyl substances in environmental waters

Lockwood, TE Talebi, M Minett, A Mills, S Doble, PA

Bishop, DP

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Publication Type:: Journal Article
Citation:: Journal of Chromatography A, 2019, 1604
Issue Date:: 2019-10-25

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Field	Value	Language
dc.contributor.author	Lockwood, TE	en_US
dc.contributor.author	Talebi, M	en_US
dc.contributor.author	Minett, A	en_US
dc.contributor.author	Mills, S	en_US
dc.contributor.author	Doble, PA https://orcid.org/0000-0002-8472-1301	en_US
dc.contributor.author	Bishop, DP https://orcid.org/0000-0002-6533-4410	en_US
dc.date.available	2019-08-27	en_US
dc.date.issued	2019-10-25	en_US
dc.identifier.citation	Journal of Chromatography A, 2019, 1604	en_US
dc.identifier.issn	0021-9673	en_US
dc.identifier.uri	http://hdl.handle.net/10453/136084
dc.description.abstract	© 2019 Growing concern over the environmental and health impacts of per- and polyfluoroalkyl substances (PFASs) has led to the development of increasingly stringent regulatory guidelines. To meet these guidelines for the determination of PFASs in surface-water, solid-phase extraction (SPE) is commonly implemented for clean-up and pre-concentration of samples. In this paper a micro-SPE method for the clean-up and pre-concentration of PFASs from surface-water was developed. A micro-SPE packing phase was created to retain 13 long and short chain PFAS after examining combinations of four 3 µm particle size sorbents, with the optimal phase consisting of a 50:50 mixture of C18 and aminopropyl silica. Micro-SPE achieved similar results to conventional SPE methods while reducing sample preparation time to 5 min and using only 2 mL of sample. The method was validated using spiked recoveries (100 ng L−1) from PFAS contaminated surface-water samples with recoveries ranging from 86% to 111% and relative standard deviations below 18%. Concentrations of the PFASs in the samples ranged from below the limit of quantification to 898 ± 15 ng L−1. Automation of sample preparation, including the micro-SPE extraction, was also demonstrated. These results show the potential for automated micro-SPE to replace conventional SPE, with the decreases in sample preparation time, sample and solvent volumes crucial for incorporation into routine analyses in commercial laboratories.	en_US
dc.relation	http://purl.org/au-research/grants/arc/DP170100036
dc.relation	http://purl.org/au-research/grants/arc/DP190102361
dc.relation.ispartof	Journal of Chromatography A	en_US
dc.relation.isbasedon	10.1016/j.chroma.2019.460495	en_US
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject.classification	Analytical Chemistry	en_US
dc.subject.mesh	Fluorocarbons	en_US
dc.subject.mesh	Solvents	en_US
dc.subject.mesh	Water Pollutants, Chemical	en_US
dc.subject.mesh	Reproducibility of Results	en_US
dc.subject.mesh	Reference Standards	en_US
dc.subject.mesh	Solid Phase Microextraction	en_US
dc.subject.mesh	Limit of Detection	en_US
dc.title	Micro solid-phase extraction for the analysis of per- and polyfluoroalkyl substances in environmental waters	en_US
dc.type	Journal Article
utslib.citation.volume	1604	en_US
utslib.for	0502 Environmental Science and Management	en_US
utslib.for	0301 Analytical Chemistry	en_US
utslib.for	03 Chemical Sciences	en_US
utslib.for	09 Engineering	en_US
utslib.for	10 Technology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - CFS - Centre for Forensic Science
utslib.copyright.status	recently_added	*
pubs.publication-status	Published	en_US
pubs.volume	1604	en_US

Abstract:

© 2019 Growing concern over the environmental and health impacts of per- and polyfluoroalkyl substances (PFASs) has led to the development of increasingly stringent regulatory guidelines. To meet these guidelines for the determination of PFASs in surface-water, solid-phase extraction (SPE) is commonly implemented for clean-up and pre-concentration of samples. In this paper a micro-SPE method for the clean-up and pre-concentration of PFASs from surface-water was developed. A micro-SPE packing phase was created to retain 13 long and short chain PFAS after examining combinations of four 3 µm particle size sorbents, with the optimal phase consisting of a 50:50 mixture of C18 and aminopropyl silica. Micro-SPE achieved similar results to conventional SPE methods while reducing sample preparation time to 5 min and using only 2 mL of sample. The method was validated using spiked recoveries (100 ng L−1) from PFAS contaminated surface-water samples with recoveries ranging from 86% to 111% and relative standard deviations below 18%. Concentrations of the PFASs in the samples ranged from below the limit of quantification to 898 ± 15 ng L−1. Automation of sample preparation, including the micro-SPE extraction, was also demonstrated. These results show the potential for automated micro-SPE to replace conventional SPE, with the decreases in sample preparation time, sample and solvent volumes crucial for incorporation into routine analyses in commercial laboratories.

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http://hdl.handle.net/10453/136084