MnO <inf>2</inf> -Disguised Upconversion Hybrid Nanocomposite: An Ideal Architecture for Tumor Microenvironment-Triggered UCL/MR Bioimaging and Enhanced Chemodynamic Therapy

Ding, B; Shao, S; Jiang, F; Dang, P; Sun, C; Huang, S; Ma, P; Jin, D; Kheraif, AAA; Lin, J

MnO <inf>2</inf> -Disguised Upconversion Hybrid Nanocomposite: An Ideal Architecture for Tumor Microenvironment-Triggered UCL/MR Bioimaging and Enhanced Chemodynamic Therapy

Ding, B Shao, S Jiang, F Dang, P Sun, C Huang, S Ma, P Jin, D

Kheraif, AAA Lin, J

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Publication Type:: Journal Article
Citation:: Chemistry of Materials, 2019
Issue Date:: 2019-01-01

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Field	Value	Language
dc.contributor.author	Ding, B	en_US
dc.contributor.author	Shao, S	en_US
dc.contributor.author	Jiang, F	en_US
dc.contributor.author	Dang, P	en_US
dc.contributor.author	Sun, C	en_US
dc.contributor.author	Huang, S	en_US
dc.contributor.author	Ma, P	en_US
dc.contributor.author	Jin, D https://orcid.org/0000-0003-1046-2666	en_US
dc.contributor.author	Kheraif, AAA	en_US
dc.contributor.author	Lin, J	en_US
dc.date.issued	2019-01-01	en_US
dc.identifier.citation	Chemistry of Materials, 2019	en_US
dc.identifier.issn	0897-4756	en_US
dc.identifier.uri	http://hdl.handle.net/10453/136100
dc.description.abstract	Copyright © 2019 American Chemical Society. Upconversion nanoparticles (UCNPs) and MnO 2 hybrid theranostic nanoplatform (UCMn) is highly desired; however, the rational design of such UCMn hybrid nanomaterials is still a great challenge. Herein, a simple and versatile strategy for the in situ growth of MnO 2 on the surfaces of UCNPs was reported using a sacrificial template method to construct an ideal MnO 2 -disguised and tumor microenvironment-triggered architecture. Such sophisticated architecture not only achieves activatable magnetic resonance imaging and restorable upconversion luminescence (UCL) imaging with over 100-fold enhancement of UCL in vivo but also significantly improves the efficiency of chemodynamic therapy (CDT) by glutathione depletion- and cisplatin-activation-enhanced • OH generation simultaneously. Additionally, the synergetic effect of CDT and chemotherapy presents excellent therapeutic effect in vivo as compared to either CDT or chemotherapy alone. We believe that the ideal design of the MnO 2 -disguised upconversion hybrid nanocomposite will provide more revelations on the future research on nanoscale theranostic systems.	en_US
dc.relation.ispartof	Chemistry of Materials	en_US
dc.relation.isbasedon	10.1021/acs.chemmater.9b00893	en_US
dc.subject.classification	Materials	en_US
dc.title	MnO <inf>2</inf> -Disguised Upconversion Hybrid Nanocomposite: An Ideal Architecture for Tumor Microenvironment-Triggered UCL/MR Bioimaging and Enhanced Chemodynamic Therapy	en_US
dc.type	Journal Article
utslib.for	0303 Macromolecular and Materials Chemistry	en_US
utslib.for	03 Chemical Sciences	en_US
utslib.for	09 Engineering	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
pubs.organisational-group	/University of Technology Sydney/Strength - IBMD - Initiative for Biomedical Devices
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US

Abstract:

Copyright © 2019 American Chemical Society. Upconversion nanoparticles (UCNPs) and MnO 2 hybrid theranostic nanoplatform (UCMn) is highly desired; however, the rational design of such UCMn hybrid nanomaterials is still a great challenge. Herein, a simple and versatile strategy for the in situ growth of MnO 2 on the surfaces of UCNPs was reported using a sacrificial template method to construct an ideal MnO 2 -disguised and tumor microenvironment-triggered architecture. Such sophisticated architecture not only achieves activatable magnetic resonance imaging and restorable upconversion luminescence (UCL) imaging with over 100-fold enhancement of UCL in vivo but also significantly improves the efficiency of chemodynamic therapy (CDT) by glutathione depletion- and cisplatin-activation-enhanced • OH generation simultaneously. Additionally, the synergetic effect of CDT and chemotherapy presents excellent therapeutic effect in vivo as compared to either CDT or chemotherapy alone. We believe that the ideal design of the MnO 2 -disguised upconversion hybrid nanocomposite will provide more revelations on the future research on nanoscale theranostic systems.

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http://hdl.handle.net/10453/136100