Moderate physical activity as a prevention method for knee osteoarthritis and the role of synoviocytes as biological key

Castrogiovanni, P; Di Rosa, M; Ravalli, S; Castorina, A; Guglielmino, C; Imbesi, R; Vecchio, M; Drago, F; Szychlinska, MA; Musumeci, G

Moderate physical activity as a prevention method for knee osteoarthritis and the role of synoviocytes as biological key

Castrogiovanni, P Di Rosa, M Ravalli, S Castorina, A

Guglielmino, C Imbesi, R Vecchio, M Drago, F Szychlinska, MA Musumeci, G

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Publication Type:: Journal Article
Citation:: International Journal of Molecular Sciences, 2019, 20 (3)
Issue Date:: 2019-02-01

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Field	Value	Language
dc.contributor.author	Castrogiovanni, P	en_US
dc.contributor.author	Di Rosa, M	en_US
dc.contributor.author	Ravalli, S	en_US
dc.contributor.author	Castorina, A https://orcid.org/0000-0001-7037-759X	en_US
dc.contributor.author	Guglielmino, C	en_US
dc.contributor.author	Imbesi, R	en_US
dc.contributor.author	Vecchio, M	en_US
dc.contributor.author	Drago, F	en_US
dc.contributor.author	Szychlinska, MA	en_US
dc.contributor.author	Musumeci, G	en_US
dc.date.available	2019-01-23	en_US
dc.date.issued	2019-02-01	en_US
dc.identifier.citation	International Journal of Molecular Sciences, 2019, 20 (3)	en_US
dc.identifier.issn	1661-6596	en_US
dc.identifier.uri	http://hdl.handle.net/10453/136103
dc.description.abstract	© 2019 by the authors. Licensee MDPI, Basel, Switzerland. The purpose of this study was to investigate the influence of moderate physical activity (MPA) on the expression of osteoarthritis (OA)-related (IL-1β, IL-6, TNF-α, MMP-13) and anti-inflammatory and chondroprotective (IL-4, IL-10, lubricin) biomarkers in the synovium of an OA-induced rat model. A total of 32 rats were divided into four groups: Control rats (Group 1); rats performing MPA (Group 2); anterior cruciate ligament transection (ACLT)-rats with OA (Group 3); and, ACLT-rats performing MPA (Group 4). Analyses were performed using Hematoxylin & Eosin (H&E) staining, histomorphometry and immunohistochemistry. In Group 3, OA biomarkers were significantly increased, whereas, IL-4, IL-10, and lubricin were significantly lower than in the other experimental groups. We hypothesize that MPA might partake in rescuing type B synoviocyte dysfunction at the early stages of OA, delaying the progression of the disease.	en_US
dc.relation.ispartof	International Journal of Molecular Sciences	en_US
dc.relation.isbasedon	10.3390/ijms20030511	en_US
dc.subject.classification	Chemical Physics	en_US
dc.subject.mesh	Animals	en_US
dc.subject.mesh	Rats	en_US
dc.subject.mesh	Osteoarthritis, Knee	en_US
dc.subject.mesh	Disease Models, Animal	en_US
dc.subject.mesh	Tumor Necrosis Factor-alpha	en_US
dc.subject.mesh	Transcription Factors	en_US
dc.subject.mesh	Interleukin-4	en_US
dc.subject.mesh	Interleukin-6	en_US
dc.subject.mesh	Interleukin-10	en_US
dc.subject.mesh	Cytokines	en_US
dc.subject.mesh	Physical Conditioning, Animal	en_US
dc.subject.mesh	Male	en_US
dc.subject.mesh	Interleukin-1beta	en_US
dc.subject.mesh	Anterior Cruciate Ligament Injuries	en_US
dc.subject.mesh	Synoviocytes	en_US
dc.title	Moderate physical activity as a prevention method for knee osteoarthritis and the role of synoviocytes as biological key	en_US
dc.type	Journal Article
utslib.citation.volume	3	en_US
utslib.citation.volume	20	en_US
utslib.for	0304 Medicinal and Biomolecular Chemistry	en_US
utslib.for	1103 Clinical Sciences	en_US
utslib.for	0399 Other Chemical Sciences	en_US
utslib.for	0604 Genetics	en_US
utslib.for	0699 Other Biological Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access
pubs.issue	3	en_US
pubs.publication-status	Published	en_US
pubs.volume	20	en_US

Abstract:

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. The purpose of this study was to investigate the influence of moderate physical activity (MPA) on the expression of osteoarthritis (OA)-related (IL-1β, IL-6, TNF-α, MMP-13) and anti-inflammatory and chondroprotective (IL-4, IL-10, lubricin) biomarkers in the synovium of an OA-induced rat model. A total of 32 rats were divided into four groups: Control rats (Group 1); rats performing MPA (Group 2); anterior cruciate ligament transection (ACLT)-rats with OA (Group 3); and, ACLT-rats performing MPA (Group 4). Analyses were performed using Hematoxylin & Eosin (H&E) staining, histomorphometry and immunohistochemistry. In Group 3, OA biomarkers were significantly increased, whereas, IL-4, IL-10, and lubricin were significantly lower than in the other experimental groups. We hypothesize that MPA might partake in rescuing type B synoviocyte dysfunction at the early stages of OA, delaying the progression of the disease.

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http://hdl.handle.net/10453/136103