Perineuronal Nets: Plasticity, Protection, and Therapeutic Potential

Reichelt, AC; Hare, DJ; Bussey, TJ; Saksida, LM

Perineuronal Nets: Plasticity, Protection, and Therapeutic Potential

Reichelt, AC Hare, DJ

Bussey, TJ Saksida, LM

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Publication Type:: Journal Article
Citation:: Trends in Neurosciences, 2019, 42 (7), pp. 458 - 470
Issue Date:: 2019-07-01

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Field	Value	Language
dc.contributor.author	Reichelt, AC	en_US
dc.contributor.author	Hare, DJ https://orcid.org/0000-0002-5922-7643	en_US
dc.contributor.author	Bussey, TJ	en_US
dc.contributor.author	Saksida, LM	en_US
dc.date.available	2019-04-22	en_US
dc.date.issued	2019-07-01	en_US
dc.identifier.citation	Trends in Neurosciences, 2019, 42 (7), pp. 458 - 470	en_US
dc.identifier.issn	0166-2236	en_US
dc.identifier.uri	http://hdl.handle.net/10453/136138
dc.description.abstract	© 2019 Elsevier Ltd The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround inhibitory parvalbumin interneurons, playing roles as both a regulator of synaptic plasticity and a protective barrier. PNNs have a delayed developmental trajectory and are key components in the closure of critical periods of heightened neuroplasticity. In animal models, manipulating PNNs outside this critical window can enhance cognition, suggesting a potentially therapeutic approach for attenuating cognitive decline. However, the crucial role of PNNs in plasticity and protection means that such therapeutic modulation must strike a careful balance: manipulation of PNNs to promote plasticity may have unintended negative consequences resulting from excessive plasticity or from exposure of neurons to neurotoxins.	en_US
dc.relation.ispartof	Trends in Neurosciences	en_US
dc.relation.isbasedon	10.1016/j.tins.2019.04.003	en_US
dc.subject.classification	Neurology & Neurosurgery	en_US
dc.title	Perineuronal Nets: Plasticity, Protection, and Therapeutic Potential	en_US
dc.type	Journal Article
utslib.citation.volume	7	en_US
utslib.citation.volume	42	en_US
utslib.for	1109 Neurosciences	en_US
utslib.for	1702 Cognitive Sciences	en_US
utslib.for	1701 Psychology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Mathematical and Physical Sciences
utslib.copyright.status	closed_access
pubs.issue	7	en_US
pubs.publication-status	Published	en_US
pubs.volume	42	en_US

Abstract:

© 2019 Elsevier Ltd The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround inhibitory parvalbumin interneurons, playing roles as both a regulator of synaptic plasticity and a protective barrier. PNNs have a delayed developmental trajectory and are key components in the closure of critical periods of heightened neuroplasticity. In animal models, manipulating PNNs outside this critical window can enhance cognition, suggesting a potentially therapeutic approach for attenuating cognitive decline. However, the crucial role of PNNs in plasticity and protection means that such therapeutic modulation must strike a careful balance: manipulation of PNNs to promote plasticity may have unintended negative consequences resulting from excessive plasticity or from exposure of neurons to neurotoxins.

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http://hdl.handle.net/10453/136138