Phytosterol biosynthesis and production by diatoms (Bacillariophyceae)

Jaramillo-Madrid, AC; Ashworth, J; Fabris, M; Ralph, PJ

Phytosterol biosynthesis and production by diatoms (Bacillariophyceae)

Jaramillo-Madrid, AC Ashworth, J

Fabris, M

Ralph, PJ

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Publication Type:: Journal Article
Citation:: Phytochemistry, 2019, 163 pp. 46 - 57
Issue Date:: 2019-07-01

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Field	Value	Language
dc.contributor.author	Jaramillo-Madrid, AC	en_US
dc.contributor.author	Ashworth, J https://orcid.org/0000-0003-4835-6551	en_US
dc.contributor.author	Fabris, M https://orcid.org/0000-0003-2910-2089	en_US
dc.contributor.author	Ralph, PJ https://orcid.org/0000-0002-3103-7346	en_US
dc.date.available	2019-03-22	en_US
dc.date.issued	2019-07-01	en_US
dc.identifier.citation	Phytochemistry, 2019, 163 pp. 46 - 57	en_US
dc.identifier.issn	0031-9422	en_US
dc.identifier.uri	http://hdl.handle.net/10453/136206
dc.description.abstract	© 2019 Elsevier Ltd Diatoms are abundant unicellular marine photosynthetic algae that have genetically diversified their physiology and metabolism while adapting to numerous environments. The metabolic repertoire of diatoms presents opportunities to characterise the biosynthesis and production of new and potentially valuable microalgal compounds, including sterols. Sterols of plant origin, known as phytosterols, have been studied for health benefits including demonstrated cholesterol-lowering properties. In this review we summarise sterol diversity, the unique metabolic features of sterol biosynthesis in diatoms, and prospects for the extraction of diatom phytosterols in comparison to existing sources. We also review biotechnological efforts to manipulate diatom biosynthesis, including culture conditions and avenues for the rational engineering of metabolism and cellular regulation.	en_US
dc.relation	http://purl.org/au-research/grants/arc/DE160100615
dc.relation.ispartof	Phytochemistry	en_US
dc.relation.isbasedon	10.1016/j.phytochem.2019.03.018	en_US
dc.subject.classification	Plant Biology & Botany	en_US
dc.subject.mesh	Diatoms	en_US
dc.subject.mesh	Phytosterols	en_US
dc.subject.mesh	Molecular Structure	en_US
dc.title	Phytosterol biosynthesis and production by diatoms (Bacillariophyceae)	en_US
dc.type	Journal Article
utslib.citation.volume	163	en_US
utslib.for	0305 Organic Chemistry	en_US
utslib.for	03 Chemical Sciences	en_US
utslib.for	06 Biological Sciences	en_US
utslib.for	11 Medical and Health Sciences	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Strength - C3 - Climate Change Cluster
utslib.copyright.status	closed_access
pubs.publication-status	Published	en_US
pubs.volume	163	en_US

Abstract:

© 2019 Elsevier Ltd Diatoms are abundant unicellular marine photosynthetic algae that have genetically diversified their physiology and metabolism while adapting to numerous environments. The metabolic repertoire of diatoms presents opportunities to characterise the biosynthesis and production of new and potentially valuable microalgal compounds, including sterols. Sterols of plant origin, known as phytosterols, have been studied for health benefits including demonstrated cholesterol-lowering properties. In this review we summarise sterol diversity, the unique metabolic features of sterol biosynthesis in diatoms, and prospects for the extraction of diatom phytosterols in comparison to existing sources. We also review biotechnological efforts to manipulate diatom biosynthesis, including culture conditions and avenues for the rational engineering of metabolism and cellular regulation.

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http://hdl.handle.net/10453/136206