The Effect of Flavored E-cigarettes on Murine Allergic Airways Disease

Chapman, DG; Casey, DT; Ather, JL; Aliyeva, M; Daphtary, N; Lahue, KG; van der Velden, JL; Janssen-Heininger, YMW; Irvin, CG

The Effect of Flavored E-cigarettes on Murine Allergic Airways Disease

Chapman, DG

Casey, DT Ather, JL Aliyeva, M Daphtary, N Lahue, KG van der Velden, JL Janssen-Heininger, YMW Irvin, CG

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Publication Type:: Journal Article
Citation:: Scientific Reports, 2019, 9 (1)
Issue Date:: 2019-12-01

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Field	Value	Language
dc.contributor.author	Chapman, DG https://orcid.org/0000-0002-8211-1817	en_US
dc.contributor.author	Casey, DT	en_US
dc.contributor.author	Ather, JL	en_US
dc.contributor.author	Aliyeva, M	en_US
dc.contributor.author	Daphtary, N	en_US
dc.contributor.author	Lahue, KG	en_US
dc.contributor.author	van der Velden, JL	en_US
dc.contributor.author	Janssen-Heininger, YMW	en_US
dc.contributor.author	Irvin, CG	en_US
dc.date.available	2019-09-09	en_US
dc.date.issued	2019-12-01	en_US
dc.identifier.citation	Scientific Reports, 2019, 9 (1)	en_US
dc.identifier.uri	http://hdl.handle.net/10453/136326
dc.description.abstract	© 2019, The Author(s). Flavored e-cigarettes are preferred by the majority of users yet their potential toxicity is unknown. Therefore our aim was to determine the effect of selected flavored e-cigarettes, with or without nicotine, on allergic airways disease in mice. Balb/c mice were challenged with PBS or house dust mite (HDM) (Days 0, 7, 14–18) and exposed to room air or e-cigarette aerosol for 30 min twice daily, 6 days/week from Days 0–18 (n = 8–12/group). Mice were exposed to Room Air, vehicle control (50%VG/%50PG), Black Licorice, Kola, Banana Pudding or Cinnacide without or with 12 mg/mL nicotine. Mice were assessed at 72 hours after the final HDM challenge. Compared to mice challenged with HDM and exposed to Room Air, nicotine-free Cinnacide reduced airway inflammation (p = 0.045) and increased peripheral airway hyperresponsiveness (p = 0.02), nicotine-free Banana Pudding increased soluble lung collagen (p = 0.049), with a trend towards increased airway inflammation with nicotine-free Black Licorice exposure (p = 0.089). In contrast, all e-cigarettes containing nicotine suppressed airway inflammation (p < 0.001 for all) but did not alter airway hyperresponsiveness or airway remodeling. Flavored e-cigarettes without nicotine had significant but heterogeneous effects on features of allergic airways disease. This suggests that some flavored e-cigarettes may alter asthma pathophysiology even when used without nicotine.	en_US
dc.relation.ispartof	Scientific Reports	en_US
dc.relation.isbasedon	10.1038/s41598-019-50223-y	en_US
dc.title	The Effect of Flavored E-cigarettes on Murine Allergic Airways Disease	en_US
dc.type	Journal Article
utslib.citation.volume	1	en_US
utslib.citation.volume	9	en_US
utslib.for	1102 Cardiorespiratory Medicine and Haematology	en_US
utslib.for	0601 Biochemistry and Cell Biology	en_US
pubs.embargo.period	Not known	en_US
pubs.organisational-group	/University of Technology Sydney
pubs.organisational-group	/University of Technology Sydney/Faculty of Science
pubs.organisational-group	/University of Technology Sydney/Faculty of Science/School of Life Sciences
utslib.copyright.status	open_access
pubs.issue	1	en_US
pubs.publication-status	Published	en_US
pubs.volume	9	en_US

Abstract:

© 2019, The Author(s). Flavored e-cigarettes are preferred by the majority of users yet their potential toxicity is unknown. Therefore our aim was to determine the effect of selected flavored e-cigarettes, with or without nicotine, on allergic airways disease in mice. Balb/c mice were challenged with PBS or house dust mite (HDM) (Days 0, 7, 14–18) and exposed to room air or e-cigarette aerosol for 30 min twice daily, 6 days/week from Days 0–18 (n = 8–12/group). Mice were exposed to Room Air, vehicle control (50%VG/%50PG), Black Licorice, Kola, Banana Pudding or Cinnacide without or with 12 mg/mL nicotine. Mice were assessed at 72 hours after the final HDM challenge. Compared to mice challenged with HDM and exposed to Room Air, nicotine-free Cinnacide reduced airway inflammation (p = 0.045) and increased peripheral airway hyperresponsiveness (p = 0.02), nicotine-free Banana Pudding increased soluble lung collagen (p = 0.049), with a trend towards increased airway inflammation with nicotine-free Black Licorice exposure (p = 0.089). In contrast, all e-cigarettes containing nicotine suppressed airway inflammation (p < 0.001 for all) but did not alter airway hyperresponsiveness or airway remodeling. Flavored e-cigarettes without nicotine had significant but heterogeneous effects on features of allergic airways disease. This suggests that some flavored e-cigarettes may alter asthma pathophysiology even when used without nicotine.

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http://hdl.handle.net/10453/136326